ArticleInfection and immunity2001
Pneumococcal conjugate vaccines overcome splenic dependency of antibody response to pneumococcal polysaccharides.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Pneumococcal vaccines for sickle cell disease.The Cochrane database of systematic reviews · 2004Pooled it
- Immune response to meningococcal serogroup C conjugate vaccine in asplenic individuals.Infection and immunity · 2004Trial
- Article
- A Review of Vaccinations in Adult Patients with Secondary Immunodeficiency.Infectious diseases and therapy · 2021Review
- Review
- Precision immunization: a new trend in human vaccination.Human vaccines & immunotherapeutics · 2020Review
- Sporadic isolated congenital asplenia with fulminant pneumococcal meningitis: a case report and updated literature review.BMC infectious diseases · 2017Review
- Immunogenicity of pneumococcal vaccination in a patient with sickle hemoglobinopathy: a case report.Clinical case reports · 2015Article
- How the Knowledge of Interactions between Meningococcus and the Human Immune System Has Been Used to Prepare Effective Neisseria meningitidis Vaccines.Journal of immunology research · 2015Review
- Is it worth investigating splenic function in patients with celiac disease?World journal of gastroenterology · 2013Review
- Meningococcal glycoconjugate vaccines.Human vaccines · 2011Review
- Depletion of complement has distinct effects on the primary and secondary antibody responses to a conjugate of pneumococcal serotype 14 capsular polysaccharide and a T-cell-dependent protein carrier.Infection and immunity · 2005Article
- After chemotherapy, functional humoral response capacity is restored before complete restoration of lymphoid compartments.Clinical and experimental immunology · 2003Article
- The dual function of the splenic marginal zone: essential for initiation of anti-TI-2 responses but also vital in the general first-line defense against blood-borne antigens.Clinical and experimental immunology · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protection against infections with Streptococcus pneumoniae depends on the presence of antibodies against capsular polysaccharides that facilitate phagocytosis. Asplenic patients are at increased risk for pneumococcal infections, since both phagocytosis and the initiation of the antibody response to polysaccharides take place in the spleen. Therefore, vaccination with pneumococcal polysaccharide vaccines is recommended prior to splenectomy, which, as in the case of trauma, is not always feasible. We show that in rats, vaccination with a pneumococcal conjugate vaccine can induce good antibody responses even after splenectomy, particularly after a second dose. The spleen remains necessary for a fast, primary response to (blood-borne) polysaccharides, even when they are presented in a conjugated form. Coadministration of a conjugate vaccine with additional nonconjugated polysaccharides of other serotypes did not improve the response to the nonconjugated polysaccharides. We conclude that pneumococcal conjugate vaccines can be of value in protecting asplenic or hyposplenic patients against pneumococcal infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.