ArticleInfection and immunity2001
Group A streptococci bind to mucin and human pharyngeal cells through sialic acid-containing receptors.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 104 citations in OpenAlex.
- Host Proteome Remodeling During Group A Streptococcus Skin Infection.Molecular & cellular proteomics : MCP · 2026Article
- Evaluation of Peptide-Based Vaccines AgainstVaccines · 2025Article
- Glycan-mediated adhesion mechanisms in antibiotic-resistant bacteria.BBA advances · 2025Article
- Human Enterovirus D68 infection - the intricate dance of cells, genes, and invading bugs.Frontiers in cellular and infection microbiology · 2025Article
- Interplay between group AMicrobiology and molecular biology reviews : MMBR · 2024Review
- Pathogenesis, epidemiology and control of Group A Streptococcus infection.Nature reviews. Microbiology · 2023Review
- The development of a 3D-printed in vitro integrated oro-pharyngeal air-liquid interface cellular throat model for drug transport.Drug delivery and translational research · 2023Article
- The exploitation of human glycans by Group A Streptococcus.FEMS microbiology reviews · 2022Article
- How bacteria utilize sialic acid during interactions with the host: snip, snatch, dispatch, match and attach.Microbiology (Reading, England) · 2022Review
- An optimised GAS-pharyngeal cell biofilm model.Scientific reports · 2021Article
- Neuraminidase B controls neuraminidase A-dependent mucus production and evasion.PLoS pathogens · 2021Article
- Defensive Properties of Mucin Glycoproteins during Respiratory Infections-Relevance for SARS-CoV-2.mBio · 2020Review
- Surface Proteins on Gram-Positive Bacteria.Microbiology spectrum · 2019Review
- Group AMicrobiology spectrum · 2019Article
- Engineering the Mucus Barrier.Annual review of biomedical engineering · 2018Review
- Lipids alter microbial transport through intestinal mucus.PloS one · 2018Article
- Fibrinogen and mucin binding activity of EF0737, a novel protein ofIranian journal of microbiology · 2017Article
- Article
- Identification of Pathogenic Factors in Klebsiella pneumoniae Using Impedimetric Sensor Equipped with Biomimetic Surfaces.Sensors (Basel, Switzerland) · 2017Article
- Blood Group Antigen Recognition via the Group A Streptococcal M Protein Mediates Host Colonization.mBio · 2017Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The first step in the colonization of group A streptococci (Streptococcus pyogenes) is adherence to pharyngeal epithelial cells. Prior to adherence to their target tissue, the first barrier that the streptococci encounter is the mucous layer of the respiratory tract. The present study was undertaken to characterize the interaction between mucin, the major glycoprotein component of mucus, and streptococci. We report here that S. pyogenes is able to bind to bovine submaxillary mucin in solid-phase microtiter plate assays. Western blots probed with (125)I-labeled mucin and a panel of monoclonal antibodies revealed that the streptococcal M protein is one of two cell wall-associated proteins responsible for this binding. The binding was further localized to the N-terminal portion of the M molecule. Further analysis revealed that the M protein binds to the sialic acid moieties on mucin, and this interaction seems to be based on M-protein conformation rather than specific amino acid sequences. We found that sialic acid also plays a critical role in the adherence of an M6 streptococcal strain to the Detroit 562 human pharyngeal cell line and have identified alpha2-6-linked sialic acid as an important sialylated linkage for M-protein recognition. Western blot analysis of extracted pharyngeal cell membrane proteins identified three potential sialic acid-containing receptors for the M protein. The results are the first to show that sialic acid not only is involved in the binding of the streptococci to mucin but also plays an important role in adherence of group A streptococci to the pharyngeal cell surface.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.