ArticleInfection and immunity2001
Nippocystatin, a cysteine protease inhibitor from Nippostrongylus brasiliensis, inhibits antigen processing and modulates antigen-specific immune response.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 127 citations in OpenAlex.
- Modulation of the Immune Response by Nematode Derived Molecules.International journal of molecular sciences · 2025Review
- Comprehensive antigen identification and comparative analysis: significant approaches for controllingJournal of veterinary science · 2025Review
- Helminth-derived molecules: Pathogenic and pharmacopeial roles.Journal of biomedical research · 2024Article
- A novel cystatin in Psoroptes ovis var. cuniculi: molecular characterization, serodiagnostic potential, and its anti-inflammatory property on rabbit peripheral blood mononuclear cells.Parasites & vectors · 2024Article
- The Secretome of Adult Murine Hookworms Is Shaped by Host Expression of STAT6.Parasite immunology · 2024Article
- Cystatin from the helminthFrontiers in immunology · 2024Article
- Hookworms dynamically respond to loss of Type 2 immune pressure.PLoS pathogens · 2023Article
- Article
- A novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae regulates inflammasome activation through the TLR4-ROS-NLRP3 pathway.Parasites & vectors · 2022Article
- Administration of Hookworm Excretory/Secretory Proteins Improves Glucose Tolerance in a Mouse Model of Type 2 Diabetes.Biomolecules · 2022Article
- Regulatory effects of a novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae on mice immune cells.Parasites & vectors · 2022Article
- The yin and yang of human soil-transmitted helminth infections.International journal for parasitology · 2021Review
- Rodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach.Frontiers in cellular and infection microbiology · 2021Review
- The Functional Parasitic Worm Secretome: Mapping the Place ofPathogens (Basel, Switzerland) · 2020Review
- Bioinformatics analysis and characterization of a secretory cystatin from Thelohanellus kitauei.AMB Express · 2020Article
- Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches.BMC genomics · 2020Article
- A novel cystatin derived from Trichinella spiralis suppresses macrophage-mediated inflammatory responses.PLoS neglected tropical diseases · 2020Article
- What Can Parasites Tell Us About the Pathogenesis and Treatment of Asthma and Allergic Diseases.Frontiers in immunology · 2020Review
- Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and Schistosomes.Frontiers in immunology · 2020Review
- Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules.Immunity · 2018Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During infection, parasites evade the host immune system by modulating or exploiting the immune system; e.g., they suppress expression of major histocompatibility complex class II molecules or secrete cytokine-like molecules. However, it is not clear whether helminths disturb the immune responses of their hosts by controlling the antigen-processing pathways of the hosts. In this study, we identified a new cysteine protease inhibitor, nippocystatin, derived from excretory-secretory (ES) products of an intestinal nematode, Nippostrongylus brasiliensis. Nippocystatin, which belongs to cystatin family 2, consists of 144 amino acids and is secreted as a 14-kDa mature form. In vivo treatment of ovalbumin (OVA)-immunized mice with recombinant nippocystatin (rNbCys) profoundly suppressed OVA-specific proliferation of splenocytes but not non-antigen-specific proliferation of splenocytes. OVA-specific cytokine production was also greatly suppressed in rNbCys-treated mice. Although the serum levels of both OVA-specific immunoglobulin G1 (IgG1) and IgG2a were not affected by rNbCys treatment, OVA-specific IgE was preferentially downregulated in rNbCys-treated mice. In vitro rNbCys inhibited processing of OVA by lysosomal cysteine proteases from the spleens of mice. Mice with anti-nippocystatin antibodies became partially resistant to infection with N. brasiliensis. Based on these findings, N. brasiliensis appears to skillfully evade host immune systems by secreting nippocystatin, which modulates antigen processing in antigen-presenting cells of hosts.
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