ArticleInfection and immunity2001
Role of the classical pathway of complement activation in experimentally induced polymicrobial peritonitis.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- C1q as a target molecule to treat human disease: What do mouse studies teach us?Frontiers in immunology · 2022Pooled it
- The additive effect of IgE-mediated and pseudoallergic hypersensitivity in RBL-2H3 cells and guinea pigs.PloS one · 2026Article
- Protective role of host complement system inFrontiers in immunology · 2022Article
- Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19.Advanced drug delivery reviews · 2021Review
- The relative merits of therapies being developed to tackle inappropriate ('self'-directed) complement activation.Auto- immunity highlights · 2016Article
- Dietary exposure of 17-alpha ethinylestradiol modulates physiological endpoints and gene signaling pathways in female largemouth bass (Micropterus salmoides).Aquatic toxicology (Amsterdam, Netherlands) · 2014Article
- Complement-dependent injury and protection in a murine model of acute dextran sulfate sodium-induced colitis.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- New insights for C5a and C5a receptors in sepsis.Frontiers in immunology · 2012Article
- Distinct different contributions of the alternative and classical complement activation pathway for the innate host response during sepsis.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine.Vaccine · 2010Article
- Heavily isotype-dependent protective activities of human antibodies against vaccinia virus extracellular virion antigen B5.Journal of virology · 2009Article
- Impaired opsonization with C3b and phagocytosis of Streptococcus pneumoniae in sera from subjects with defects in the classical complement pathway.Infection and immunity · 2008Article
- Involvement of the lectin pathway of complement activation in antimicrobial immune defense during experimental septic peritonitis.Infection and immunity · 2004Article
- Dependence of positive effects of granulocyte colony-stimulating factor on the antibiotic regimen: evaluation in rats with polymicrobial peritonitis.World journal of surgery · 2004Article
- Developing animal models for polymicrobial diseases.Nature reviews. Microbiology · 2004Review
- Regulation of complement C3 and C4 synthesis in human peritoneal mesothelial cells by peritoneal dialysis fluid.Clinical and experimental immunology · 2004Article
- Evasion of phagocytosis through cooperation between two ligand-binding regions in Streptococcus pyogenes M protein.The Journal of experimental medicine · 2003Article
- Murine serine proteases MASP-1 and MASP-3, components of the lectin pathway activation complex of complement, are encoded by a single structural gene.Genes and immunity · 2003Article
- Role for the alternative complement pathway in ischemia/reperfusion injury.The American journal of pathology · 2003Article
- The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complement system and the natural antibody repertoire provide a critical first-line defense against infection. The binding of natural antibodies to microbial surfaces opsonizes invading microorganisms and activates complement via the classical pathway. Both defense systems cooperate within the innate immune response. We studied the role of the complement system in the host defense against experimental polymicrobial peritonitis using mice lacking either C1q or factor B and C2. The C1q-deficient mice lacked the classical pathway of complement activation. The factor B- and C2-deficient mice were known to lack the classical and alternative pathways, and we demonstrate here that these mice also lacked the lectin pathway of complement activation. Using inoculum doses adjusted to cause 42% mortality in the wild-type strain, none of the mice deficient in the three activation routes of complement (factor B and C2 deficient) survived (mortality of 100%). Mortality in mice deficient only in the classical pathway of complement activation (C1q deficient) was 83%. Application of further dilutions of the polymicrobial inoculum showed a dose-dependent decrease of mortality in wild-type controls, whereas no changes in mortality were observed in the two gene-targeted strains. These results demonstrate that the classical activation pathway is required for an effective antimicrobial immune defense in polymicrobial peritonitis and that, in the infection model used, the remaining antibody-independent complement activation routes (alternative and lectin pathways) provide a supporting line of defense to gain residual protection in classical pathway deficiency.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.