ArticleInfection and immunity2001
Exaggerated proinflammatory and Th1 responses in the absence of gamma/delta T cells after infection with Listeria monocytogenes.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Immunogenicity of a whole-cell pertussis vaccine with low lipopolysaccharide content in infants.Clinical and vaccine immunology : CVI · 2009Trial
- By dawn or dusk-how circadian timing rewrites bacterial infection outcomes.FEBS letters · 2026Review
- Compensatory mechanisms in γδ T cell-deficient chickens followingFrontiers in immunology · 2025Article
- Double-Negative T-Cell Reaction in a Case ofInternational journal of environmental research and public health · 2021Article
- The Systemic and Cellular Metabolic Phenotype of Infection and Immune Response toFrontiers in immunology · 2020Article
- γδ T cells provide the early source of IFN-γ to aggravate lesions in spinal cord injury.The Journal of experimental medicine · 2018Article
- Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells.Frontiers in immunology · 2018Review
- Solute carrier 11A1 is expressed by innate lymphocytes and augments their activation.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Characterization of avian γδ T-cell subsets after Salmonella enterica serovar Typhimurium infection of chicks.Infection and immunity · 2011Article
- Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Lymphocytes modulate peritoneal leukocyte recruitment in peritonitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2009Article
- Protective role of gammadelta T cells in spontaneous ocular inflammation.Investigative ophthalmology & visual science · 2009Article
- Gammadelta T cells mitigate the organ injury and mortality of sepsis.Journal of leukocyte biology · 2008Article
- gammadelta T cells regulate the early inflammatory response to bordetella pertussis infection in the murine respiratory tract.Infection and immunity · 2006Article
- CD4+ T-cell responses and distribution at the colonic mucosa during Brachyspira hyodysenteriae-induced colitis in pigs.Immunology · 2005Article
- A defective Th1 response of the spleen in the initial phase may explain why splenectomy helps prevent a Listeria infection.Clinical and experimental immunology · 2005Article
- The role of gamma/delta T cells in immunity to infection and regulation of inflammation.Immunologic research · 2004Review
- Increased host resistance against Pneumocystis carinii pneumonia in gammadelta T-cell-deficient mice: protective role of gamma interferon and CD8(+) T cells.Infection and immunity · 2002Article
- Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo.Veterinary researchArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
While gamma/delta T cells are involved in host defense and immunopathology in a variety of infectious diseases, their precise role is not yet clearly defined. In the absence of gamma/delta T cells, mice die after infection with a dose of Listeria monocytogenes that is not lethal in immunologically intact animals. Morbidity might result from insufficient levels of cytokines normally produced by gamma/delta T cells or conversely from an excess of cytokines due to a lack of down-regulation of the inflammatory response in the absence of gamma/delta T cells. Consistent with a regulatory role, we found that systemic levels of proinflammatory cytokines (interleukin-6 [IL-6], IL-12, and gamma interferon [IFN-gamma]) were significantly higher in the absence of gamma/delta T cells during the innate phase of the response. Using combinations of genetically altered and immunodepleted mice, we found evidence for gamma/delta T-cell-mediated regulation of IFN-gamma production by multiple cell types of both lymphoid and myeloid lineages. The antigen-specific alpha/beta T-cell response that followed the exaggerated innate response was also increased in gamma/delta T-cell-deficient mice. These findings are consistent with an emerging picture from a variety of immune response models of a critical role for gamma/delta T cells in down-modulation of the immune response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.