ArticleOncogene2001
One INK4 gene and no ARF at the Fugu equivalent of the human INK4A/ARF/INK4B tumour suppressor locus.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 51 citations in OpenAlex.
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- Canine Mammary Carcinomas: A Comparative Analysis of Altered Gene Expression.Veterinary sciences · 2015Review
- The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration.eLife · 2015Article
- INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish.British journal of haematology · 2014Article
- Activation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathway.Oncogenesis · 2014Article
- Embryonic Expression and Function of theCell & developmental biology · 2014Article
- Tumor suppressors: enhancers or suppressors of regeneration?Development (Cambridge, England) · 2013Article
- Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish.Cell cycle (Georgetown, Tex.) · 2011Article
- Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle.Cell stem cell · 2010Article
- Genetic and environmental melanoma models in fish.Pigment cell & melanoma research · 2010Review
- Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish.Blood · 2010Article
- p53 ancestry: gazing through an evolutionary lens.Nature reviews. Cancer · 2009Review
- Disruption of chromosome 11 in canine fibrosarcomas highlights an unusual variability of CDKN2B in dogs.BMC veterinary research · 2009Article
- Rapid asymmetric evolution of a dual-coding tumor suppressor INK4a/ARF locus contradicts its function.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.Nature reviews. Molecular cell biology · 2006Review
- Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Data mining the p53 pathway in the Fugu genome: evidence for strong conservation of the apoptotic pathway.Oncogene · 2003Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The INK4A/ARF/INK4B locus, conserved in mammals, encodes three polypeptides that regulate cell proliferation via the pRb and p53 tumour suppressor pathways. The locus is mutated in many cancers. The related, tandemly-linked INK4A and INK4B genes encode the p16(INK4A) and p15(INK4B) members of the INK4 family of cyclin-dependent kinase inhibitors which block phosphorylation of pRb, whereas the third product, ARF, derived from an alternative reading frame of INK4A, regulates p53 activity. We assessed the status of this unusual locus in the puffer fish, Fugu rubripes, and identified two INK4 genes using degenerate PCR and hybridization analyses. Sequence conservation and conservation of synteny between human and Fugu predict one gene to be an INK4A or INK4B homologue and the other an INK4D homologue. Analysis of the Fugu INK4A/B gene and the surrounding 40-kb of genomic DNA did not reveal the presence of any ARF-encoding potential or another related INK4 gene. We conclude that the gene duplication event that generated adjacent INK4A and INK4B genes and the association of ARF with the ancestral INK4A gene occurred after the divergence of the lineage leading to mammals from fish. Thus, unlike mammals, the fish p53 and pRb tumour suppressor pathways are not regulated by a single locus.
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