Evidence map›Paper›PMID 11704872›Full record

ArticleOncogene2001

Tumorigenic N-terminal deletions of c-Myb modulate DNA binding, transactivation, and cooperativity with C/EBP.

M Oelgeschläger, E Kowenz-Leutz, S Schreek, A Leutz, B Lüscher

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Evolution of the 3R-MYB Gene Family in Plants.Genome biology and evolution · 2017
    Article
  5. Myb proteins: angels and demons in normal and transformed cells.Frontiers in bioscience (Landmark edition) · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

M OelgeschlägerInstitut für Molekularbiologie, Medizinische Hochschule Hannover, 30623 Hannover, Germany.
E Kowenz-Leutz
S Schreek
A Leutz
B Lüscher
Max Delbrück Center · DEMedizinische Hochschule Hannover · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oncogenic activation of c-myb by retroviral insertion has been implicated in tumor formation in chicken and mice. These genetic alterations result in deregulated expression of the c-myb gene and frequently in N-terminal truncation of the c-Myb protein. We demonstrate that truncation of the c-Myb N-terminus affects DNA binding and reporter activation. However, all three mutants, Myb Delta N20, Myb Delta N47 and Myb Delta N71 cooperated with C/EBP beta in reporter assays. In contrast to Myb Delta N20 and Myb Delta N47, however, the Myb Delta N71 mutant failed to activate the chromatin embedded endogenous mim-1 gene together with C/EBP beta. This suggests that an N-terminal region (amino acids 47-71) within repeat 1 (R1) of the murine c-Myb DNA binding domain affects activation of chromosomal target genes in collaboration with C/EBP beta.

Indexed as

AcetyltransferasesGenes, mybAnimalsCCAAT-Enhancer-Binding Protein-betaChickensChlorocebus aethiopsCOS CellsDNADNA, NeoplasmGene Expression Regulation, NeoplasticGenes, ReporterHumansLuciferasesMacromolecular SubstancesMicePromoter Regions, GeneticAcetyltransferasesCCAAT-Enhancer-Binding Protein-betaDNADNA, NeoplasmLuciferasesMacromolecular Substancesmim-1 protein, Gallus gallusProteinsProto-Oncogene Proteins c-mybRecombinant Fusion Proteinstranscription factor NF-MTranscription Factors

Identifiers

PMID11704872
OpenAlexW2322101969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.