Evidence map›Paper›PMID 11704831›Full record

ArticleOncogene2001

The proliferative and apoptotic activities of E2F1 in the mouse retina.

S C Lin, S X Skapek, D S Papermaster, M Hankin, E Y Lee

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Functional architecture of the retina: development and disease.Progress in retinal and eye research · 2014
    Review
  2. Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  3. Article
  4. Non-coding RNAs in retinal development.International journal of molecular sciences · 2012
    Review
  5. Article
  6. Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010
    Article
  7. Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008
    Article
  8. Article
  9. DNA-damage response pathways triggered by viral replication.Expert reviews in molecular medicine · 2006
    Review
  10. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice.Proceedings of the National Academy of Sciences of the United States of America · 2003
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

S C LinDepartment of Molecular Medicine/Institute of Biotechnology, University of Texas Health Science Center at San Antonio, Texas, TX 78245-3207, USA.
S X Skapek
D S Papermaster
M Hankin
E Y Lee
The University of Texas Health Science Center at San Antonio · USSt. Jude Children's Research Hospital · USUConn Health · USUniversity of Toledo Medical Center · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
Oncogenes and loss of ER in a new p53 breast tumor modelR37CA049649 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LEE, EVA Y · 2002 to 2006
$1.5M
TUMOR SUPPRESSION FUNCTION OF RB &P53 IN MAMMARY GLANDR01CA049649 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI LEE, EVA Y · 1994 to 1998
–
CANCER SUPPRESSION &DEVELOPMENTAL FUNCTIONS OF RB GENER29CA049649 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI LEE, EVA Y · 1989 to 1993
–
NCI NIH HHS CA49649NCI NIH HHS P30 CA 54174
6 · The paper itself

Abstract

The E2F1 transcription factor controls cell proliferation and apoptosis. E2F1 activity is negatively regulated by the retinoblastoma (RB) protein. To study how inactivation of Rb and dysregulated E2F1 affects the developing retina, we analysed wild-type and Rb(-/-) embryonic retinas and retinal transplants and we established transgenic mice expressing human E2F1 in retinal photoreceptor cells under the regulation of the IRBP promoter (TgIRBPE2F1). A marked increase in cell proliferation and apoptosis was observed in the retinas of Rb(-/-) mice and TgIRBPE2F1 transgenic mice. In the transgenic mice, photoreceptor cells formed rosette-like arrangements at postnatal days 9 through 28. Complete loss of photoreceptors followed in the TgIRBPE2F1 mice but not in the Rb(-/-) retinal transplants. Both RB-deficient and E2F1-overexpressing photoreceptor cells expressed rhodopsin, a marker of terminal differentiation. Loss of p53 partially reduced the apoptosis and resulted in transient hyperplasia of multiple cell types in the TgIRBPE2F1 retinas at postnatal day 6. Our findings support the concept that cross-talk occurs between different retinal cell types and that multiple genetic pathways must become dysregulated for the full oncogenic transformation of neuronal retinal cells.

Indexed as

Cell Cycle ProteinsDNA-Binding ProteinsAnimalsApoptosisCell CycleCell DifferentiationCell DivisionDNA ReplicationE2F1 Transcription FactorE2F Transcription FactorsEye ProteinsFemaleGene Expression RegulationGenes, SyntheticHumansHyperplasiaCell Cycle ProteinsDNA-Binding ProteinsE2F1 protein, humanE2f1 protein, mouseE2F1 Transcription FactorE2F Transcription FactorsEye ProteinsRecombinant Fusion ProteinsRetinoblastoma ProteinRetinol-Binding ProteinsRetinol-Binding Proteins, InterstitialRhodopsinTranscription Factors

Identifiers

PMID11704831
OpenAlexW2322095085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.