Evidence map›Paper›PMID 11704827›Full record

ArticleOncogene2001

Induction of a TRAIL-mediated suicide program by interferon alpha in primary effusion lymphoma.

N L Toomey, V V Deyev, C Wood, L H Boise, D Scott, L H Liu, L Cabral, E R Podack, G N Barber, W J Harrington

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Type I interferons in infectious disease.Nature reviews. Immunology · 2015
    Review
  8. Current status of treatment for primary effusion lymphoma.Intractable & rare diseases research · 2014
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Efficacy of bortezomib in a direct xenograft model of primary effusion lymphoma.Proceedings of the National Academy of Sciences of the United States of America · 2010
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

N L ToomeyDepartment of Medicine, University of Miami School of Medicine, Miami, Florida, FL 33136, USA.
V V Deyev
C Wood
L H Boise
D Scott
L H Liu
L Cabral
E R Podack
G N Barber
W J Harrington
University of Miami · USUniversity of Nebraska–Lincoln · US

Funding

ANTIVIRAL MEDIATED APOPTOSIS OF NON HODGKIN'S LYMPHOMAR01CA082274 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARRINGTON, WILLIAM J · 2000 to 2007
$2.4M
MOLECULAR MECHANMISM OF LYMPHOCYTE MEDIATED TUMOR LYSISR01CA039201 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PODACK, ECKHARD R · 1985 to 2009
$2.3M
MOLECULAR MECHANISMS OF CD30+ LYMPHOMA GROWTHR01CA080228 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PODACK, ECKHARD R · 1999 to 2002
$632k
MECHANISM OF BCL-X EXPRESSION IN LYMPHOCYTES AND CANCERR29CA077837 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BOISE, LAWRENCE H · 1998 to 2002
$324k
NCI NIH HHS CA39201NCI NIH HHS CA77837NCI NIH HHS CA80228NCI NIH HHS CA82274
6 · The paper itself

Abstract

Gammaherpes viruses are often detected in lymphomas arising in immunocompromised patients. We have found that Azidothymidine (AZT) alone induces apoptosis in Epstein Barr Virus (EBV) positive Burkitt's lymphoma (BL) cells but requires interferon alpha (IFN-alpha) to induce apoptosis in Human Herpes Virus Type 8 (HHV-8) positive Primary Effusion Lymphomas (PEL). Our analysis of a series of AIDS lymphomas revealed that IFN-alpha selectively induced very high levels of the Death Receptor (DR) tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in HHV-8 positive PEL lines and primary tumor cells whereas little or no induction was observed in primary EBV+ AIDS lymphomas and EBV-Burkitt's lines. AZT and IFN-alpha mediated apoptosis in PEL was blocked by stable overexpression of dominant negative Fas Associated Death Domain (FADD), decoy receptor 2 (DcR2), soluble TRAIL receptor fusion proteins (DR-4 and DR-5) and thymidine. Trimeric TRAIL (in place of IFN-alpha) similarly synergized with AZT to induce apoptosis in HHV-8 positive PEL cells. This is the first demonstration that IFN-alpha induces functional TRAIL in a malignancy that can be exploited to effect a suicide program. This novel antiviral approach to Primary Effusion lymphomas is targeted and may represent a highly effective and relatively non-toxic therapy.

Indexed as

Arabidopsis ProteinsAntimetabolites, AntineoplasticAntiviral AgentsApoptosisApoptosis Regulatory Proteinsbcl-X ProteinBiopolymersCysteine EndopeptidasesDrug SynergismEnzyme ActivationEpstein-Barr Virus InfectionsEtoposideFatty Acid DesaturasesGene Expression Regulation, NeoplasticGenes, bcl-2Herpesviridae InfectionsAntimetabolites, AntineoplasticAntiviral AgentsApoptosis Regulatory ProteinsArabidopsis ProteinsBCL2L1 protein, humanbcl-X ProteinBiopolymersCysteine EndopeptidasesEtoposideFad7 protein, ArabidopsisFatty Acid DesaturasesImmunologic FactorsInterferon-alphaMembrane GlycoproteinsNeoplasm ProteinsProto-Oncogene Proteins c-bcl-2Receptors, TNF-Related Apoptosis-Inducing LigandReceptors, Tumor Necrosis FactorThymidineTNF-Related Apoptosis-Inducing LigandTNFRSF10A protein, humanTNFRSF10B protein, humanTNFSF10 protein, humanTumor Necrosis Factor-alphaZidovudine

Identifiers

PMID11704827
OpenAlexW2315551924

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.