ArticleBritish journal of pharmacology2001
P2 receptor-types involved in astrogliosis in vivo.
Article in British journal of pharmacology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 98 citations in OpenAlex.
- Calcium Signaling in Astrocytes and Its Role in the Central Nervous System Injury.Molecular neurobiology · 2025Review
- Current Advancements in Spinal Cord Injury Research-Glial Scar Formation and Neural Regeneration.Cells · 2023Review
- Increased expression of the P2YRenal failure · 2023Article
- Article
- Dissecting the Dual Role of the Glial Scar and Scar-Forming Astrocytes in Spinal Cord Injury.Frontiers in cellular neuroscience · 2020Article
- Moving beyond the glial scar for spinal cord repair.Nature communications · 2019Review
- The role of P2YCellular and molecular life sciences : CMLS · 2019Review
- ATP evokes CaJournal of neurochemistry · 2017Article
- Prostaglandin EFrontiers in pharmacology · 2017Article
- Short- and long-term (trophic) purinergic signalling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Effects of IP3R2 Receptor Deletion in the Ischemic Mouse Retina.Neurochemical research · 2016Article
- Enteric glia mediate neuron death in colitis through purinergic pathways that require connexin-43 and nitric oxide.Cellular and molecular gastroenterology and hepatology · 2016Article
- P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction.Neural plasticity · 2016Review
- Differential effects of P2Y1 deletion on glial activation and survival of photoreceptors and amacrine cells in the ischemic mouse retina.Cell death & disease · 2014Article
- Neuronal and glial purinergic receptors functions in neuron development and brain disease.Frontiers in cellular neuroscience · 2013Review
- Antagonism of purinergic signalling improves recovery from traumatic brain injury.Brain : a journal of neurology · 2013Article
- Pathophysiology of astroglial purinergic signalling.Purinergic signalling · 2012Review
- Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue.Journal of molecular neuroscience : MN · 2012Article
- P2Y2 receptor expression is altered in rats after spinal cord injury.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2010Article
- Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death.Cell death & disease · 2010Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
1. In the nucleus accumbens (NAc) of rats, the involvement of P2X and P2Y receptors in the generation of astrogliosis in vivo, was investigated by local application of their respective ligands. The agonists used had selectivities for P2X1,3 (alpha,beta-methylene adenosine 5'-triphosphate; alpha,beta-meATP), P2Y1,12 (adenosine 5'-O-(2-thiodiphosphate; ADP-beta-S) and P2Y2,4,6 receptors (uridine 5'-O-(3-thiotriphosphate; UTP-gamma-S). Pyridoxalphosphate-6-azophenyl-2,4-disulphonic acid (PPADS) was used as a non-selective antagonist. The astroglial reaction was studied by means of immunocytochemical double-labelling with antibodies to glial fibrillary acidic protein (GFAP) and 5-bromo-2'-deoxyuridine (BrdU). 2. The agonist-induced changes in comparison to the artificial cerebrospinal fluid (aCSF)-treated control side reveal a strong mitogenic potency of ADP-beta-S and alpha,beta-meATP, whereas UTP-gamma-S was ineffective. The P2 receptor antagonist PPADS decreased the injury-induced proliferation when given alone and in addition inhibited all agonist effects. 3. The observed morphogenic changes included hypertrophy of astrocytes, elongation of astrocytic processes and up-regulation of GFAP. A significant increase of both GFAP-immunoreactivity (IR) and GFA-protein content (by using Western blotting) was found after microinfusion of alpha,beta-meATP or ADP-beta-S. In contrast, UTP-gamma-S failed to increase the GFAP-IR. The morphogenic effects were also inhibited by pre-treatment with PPADS. 4. A double immunofluorescence approach with confocal laser scanning microscopy showed the localisation of P2X3 and P2Y1 receptors on the GFAP-labelled astrocytes. 5. In conclusion, the data suggest that P2Y (P2Y1 or P2Y12) receptor subtypes are involved in the generation of astrogliosis in the NAc of rats, with a possible minor contribution of P2X receptor subtypes.
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