Evidence map›Paper›PMID 11703537›Full record

ReviewInternational journal of experimental pathology2001

Viral escape mechanisms--escapology taught by viruses.

M Lucas, U Karrer, A Lucas, P Klenerman

Open access · greenAbstract readReview
In one paragraph

Review in International journal of experimental pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 117 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Selective Diversity in RNA Viruses: Do They Know How to Evolve? A Hypothesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  6. Over time analysis of the codon usage of SARS-CoV-2 and its variants.Computational and structural biotechnology journal · 2025
    Article
  7. Article
  8. Regulatory role of microRNAs in virus-mediated inflammation.Journal of inflammation (London, England) · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Cutaneous granulomas associated with rubella virus: A clinical review.Journal of the American Academy of Dermatology · 2024
    Review
  13. Review
  14. Review
  15. Insight into the Epigenetics of Kaposi's Sarcoma-Associated Herpesvirus.International journal of molecular sciences · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Colliding Pandemics and CoViD-19.Bioinformation · 2023
    Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

M LucasNuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK. michaela.lucas@ndm.ox.ac.uk
U Karrer
A Lucas
P Klenerman
John Radcliffe Hospital · GBUniversity of Oxford · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Viruses have 'studied' immunology over millions of years of coevolution with their hosts. During this ongoing education they have developed countless mechanisms to escape from the host's immune system. To illustrate the most common strategies of viral immune escape we have focused on two murine models of persistent infection, lymphocytic choriomeningitis virus (LCMV) and murine cytomegalovirus (MCMV). LCMV is a fast replicating small RNA virus with a genome prone to mutations. Therefore, LCMV escapes from the immune system mainly by two strategies: 'speed' and 'shape change'. At the opposite extreme, MCMV is a large, complex DNA virus with a more rigid genome and thus the strategies used by LCMV are no option. However, MCMV has the coding capacity for additional genes which interfere specifically with the immune response of the host. These escape strategies have been described as 'camouflage' and 'sabotage'. Using these simple concepts we describe the spectrum of viral escapology, giving credit not only to the researchers who uncovered this fascinating area of immunology but also to the viruses themselves, who still have a few lessons to teach.

Indexed as

AnimalsAntigens, ViralCD4 AntigensCD8 AntigensDendritic CellsKiller Cells, NaturalLymphocytic choriomeningitis virusMiceMuromegalovirusT-LymphocytesAntigens, ViralCD4 AntigensCD8 Antigens

Identifiers

PMID11703537
PMCPMC2517780
OpenAlexW1510501987

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.