ArticleClinical and experimental immunology2001
Increased secretion of IL-18 in vitro by peripheral blood mononuclear cells of patients with bronchial asthma and atopic dermatitis.
Article in Clinical and experimental immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Genetic polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 promoter may not be associated with development of hepatocellular carcinoma.Scientific reports · 2016Pooled it
- Allergy to Lipid Transfer Protein or Hypersensitivity to Non-Steroidal Anti-Inflammatory Drugs?International journal of molecular sciences · 2025Article
- Soluble factors from TLR4- or TCR-activated cells contribute to stability of the resting phenotype and increase the expression of CXCR4 of human memory CD4 T cells.Immunologic research · 2023Article
- CAR-T cells targeting HLA-G as potent therapeutic strategy for EGFR-mutated and overexpressed oral cancer.iScience · 2023Article
- The impact of 17β-estradiol and progesterone therapy on peripheral blood mononuclear cells of asthmatic patients.Molecular biology reports · 2021Article
- Clinical Signs, Staphylococcus and Atopic Eczema-Related Seromarkers.Molecules (Basel, Switzerland) · 2017Article
- Evidence for a causal relationship between respiratory syncytial virus infection and asthma.Expert review of anti-infective therapy · 2011Review
- Is interleukin-18 associated with polycystic ovary syndrome?Reproductive biology and endocrinology : RB&E · 2011Article
- Serum interleukin-18 expression in children with bronchial asthma.The World Allergy Organization journal · 2009Article
- Role of the Transcriptional Repressor BCL6 in Allergic Response and Inflammation.The World Allergy Organization journal · 2008Article
- Neutrophil activation in patients with ASA-induced urticaria.Journal of clinical immunology · 2008Article
- Association of interleukin-18 gene polymorphism with asthma in Chinese patients.Journal of clinical laboratory analysis · 2008Article
- Diesel-enriched particulate matter functionally activates human dendritic cells.American journal of respiratory cell and molecular biology · 2007Article
- Interleukin-18 genetics and inflammatory disease susceptibility.Genes and immunity · 2007Review
- Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).Clinical and molecular allergy : CMA · 2006Article
- A promoter haplotype of the interleukin-18 gene is associated with juvenile idiopathic arthritis in the Japanese population.Arthritis research & therapy · 2006Article
- Association of polymorphisms of interleukin-18 gene promoter region with chronic hepatitis B in Chinese Han population.World journal of gastroenterology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was performed to determine whether or not IL-18, formerly called IFN-gamma-inducing factor, is involved in the pathogeneses of allergic disorders. Peripheral blood mononuclear cells (PBMC) were obtained from patients with allergic bronchial asthma (BA), patients with atopic dermatitis (AD) and controls who did not have any allergic disease, and then cultured with lipopolysaccharide (LPS) or phytohaemagglutinin (PHA). The concentrations of IL-18, IFN-gamma and IL-13 in supernatant fluids were determined by enzymatic immunoassaying, and the expression of IFN-gamma messenger (m) RNA in the cells was measured by colorimetric microplate assaying. IL-18 secretion in the BA patients (geometric mean (gm) = 189 pg/ml) and AD patients (gm = 172 pg/ml) was significantly higher than that in non-allergic controls (gm = 118 pg/ml). In contrast, IFN-gamma secretion in the BA patients (gm = 7.3 IU/ml) and AD patients (gm = 6.8 IU/ml) was significantly lower than that in non-allergic controls (gm = 20.7 IU/ml). The amounts of IL-13 in supernatant fluids and IFN-gamma mRNA in cells were not statistically different among the BA patients, AD patients and non-allergic controls. The possible involvement of IL-18 in allergic disorders is discussed.
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