ArticleThe Plant cell2001
Molecular characterization of subunit 6 of the COP9 signalosome and its role in multifaceted developmental processes in Arabidopsis.
Article in The Plant cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 79 citations in OpenAlex.
- COP9 Signalosome SubunitBiology · 2025Article
- COP9 Signalosome's Role in Plant Defense Mechanisms.Plants (Basel, Switzerland) · 2025Review
- SlBBX20 interacts with the COP9 signalosome subunit SlCSN5-2 to regulate anthocyanin biosynthesis by activating SlDFR expression in tomato.Horticulture research · 2021Article
- SAP130 and CSN1 interact and regulate male gametogenesis in Arabidopsis thaliana.Journal of plant research · 2021Article
- Mapping regulatory variants controlling gene expression in drought response and tolerance in maize.Genome biology · 2020Article
- CSN6 promotes the cell migration of breast cancer cells by positively regulating Snail1 stability.International journal of medical sciences · 2020Observational
- Uncovering the molecular signature underlying the light intensity-dependent root development in Arabidopsis thaliana.BMC genomics · 2019Article
- Identification of COP9 Signalosome Subunit Genes inFrontiers in physiology · 2019Article
- Phosphorylation and negative regulation of CONSTITUTIVELY PHOTOMORPHOGENIC 1 by PINOIDProceedings of the National Academy of Sciences of the United States of America · 2017Article
- CSN6 controls the proliferation and metastasis of glioblastoma by CHIP-mediated degradation of EGFR.Oncogene · 2017Article
- CSN6, a subunit of the COP9 signalosome, is involved in early response to iron deficiency in Oryza sativa.Scientific reports · 2016Article
- CSN6 drives carcinogenesis by positively regulating Myc stability.Nature communications · 2014Article
- The CSN/COP9 signalosome regulates synaptonemal complex assembly during meiotic prophase I of Caenorhabditis elegans.PLoS genetics · 2014Article
- The RING-Finger E3 Ubiquitin Ligase COP1 SUPPRESSOR1 Negatively Regulates COP1 Abundance in Maintaining COP1 Homeostasis in Dark-Grown Arabidopsis Seedlings.The Plant cell · 2014Article
- The eta7/csn3-3 auxin response mutant of Arabidopsis defines a novel function for the CSN3 subunit of the COP9 signalosome.PloS one · 2013Article
- The organization of a CSN5-containing subcomplex of the COP9 signalosome.The Journal of biological chemistry · 2012Article
- COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ.Oncogene · 2011Article
- Roles of COP9 signalosome in cancer.Cell cycle (Georgetown, Tex.) · 2011Review
- Analysis of trehalose-6-phosphate synthase (TPS) gene family suggests the formation of TPS complexes in rice.Plant molecular biology · 2011Article
- Role of individual subunits of the Neurospora crassa CSN complex in regulation of deneddylation and stability of cullin proteins.PLoS genetics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The COP9 signalosome is a highly conserved protein complex initially identified as a repressor of photomorphogenesis. Here, we report that subunit 6 of the Arabidopsis COP9 signalosome is encoded by a family of two genes (CSN6A and CSN6B) located on chromosomes V and IV, respectively. The CSN6A and CSN6B proteins share 87% amino acid identity and contain a MPR1p and PAD1p N-terminal (MPN) domain at the N-terminal region. The CSN6 proteins share homology with CSN5 and belong to the Mov34 superfamily of proteins. CSN6 proteins present only in the complex form and coimmunoprecipitate with other known subunits of the COP9 signalosome. Partial loss-of-function strains of the COP9 signalosome created by antisense and cosuppression with CSN6A exhibit diverse developmental defects, including homeotic organ transformation, symmetric body organization, and organ boundary definition. Protein blot analysis revealed that the defective plants accumulate significant amounts of ubiquitinated proteins, supporting the conclusion that the COP9 signalosome regulates multifaceted developmental processes through its involvement in ubiquitin/proteasome-mediated protein degradation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.