ArticleProceedings of the National Academy of Sciences of the United States of America2001
Regulation of cyclic peptide biosynthesis in a plant pathogenic fungus by a novel transcription factor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 65 citations in OpenAlex.
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- A linear nonribosomal octapeptide from Fusarium graminearum facilitates cell-to-cell invasion of wheat.Nature communications · 2019Article
- Passive surveillance for azole-resistant Aspergillus fumigatus, United States, 2011-2013.Emerging infectious diseases · 2014Article
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- The Fusarium graminearum genome reveals more secondary metabolite gene clusters and hints of horizontal gene transfer.PloS one · 2014Article
- Conservation of the genes for HC-toxin biosynthesis in Alternaria jesenskae.BMC microbiology · 2013Article
- Transcriptional regulatory elements in fungal secondary metabolism.Journal of microbiology (Seoul, Korea) · 2011Review
- A test of the coordinated expression hypothesis for the origin and maintenance of the GAL cluster in yeast.PloS one · 2011Article
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- Operons.Cellular and molecular life sciences : CMLS · 2009Review
- Biz1, a zinc finger protein required for plant invasion by Ustilago maydis, regulates the levels of a mitotic cyclin.The Plant cell · 2006Article
- Organization of chromosome ends in the rice blast fungus, Magnaporthe oryzae.Nucleic acids research · 2006Article
- A gene cluster for secondary metabolism in oat: implications for the evolution of metabolic diversity in plants.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Winged helix transcription factor CPCR1 is involved in regulation of beta-lactam biosynthesis in the fungus Acremonium chrysogenum.Eukaryotic cell · 2004Article
- Characterization of inhibitor-resistant histone deacetylase activity in plant-pathogenic fungi.Eukaryotic cell · 2002Article
- Tox-boxes, fungal secondary metabolites, and plant disease.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Strains of the filamentous fungus Cochliobolus carbonum that produce the host-selective compound HC-toxin, a cyclic tetrapeptide, are highly virulent on certain genotypes of maize (Zea mays L.). Production of HC-toxin is under the control of a complex locus, TOX2, which is composed of at least seven linked and duplicated genes that are present only in toxin-producing strains of C. carbonum. One of these genes, TOXE, was earlier shown to be required for the expression of the other TOX2 genes. TOXE has four ankyrin repeats and a basic region similar to those found in basic leucine zipper (bZIP) proteins, but lacks any apparent leucine zipper. Here we show that TOXE is a DNA-binding protein that recognizes a ten-base motif (the "tox-box") without dyad symmetry that is present in the promoters of all of the known TOX2 genes. Both the basic region and the ankyrin repeats are involved in DNA binding. A region of TOXE that includes the first ankyrin repeat is necessary and sufficient for transcriptional activation in yeast. The data indicate that TOXE is the prototype of a new family of transcription factor, so far found only in plant-pathogenic fungi. TOXE plays a specific regulatory role in HC-toxin production and, therefore, pathogenicity by C. carbonum.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.