ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Self-organized synaptic plasticity contributes to the shaping of gamma and beta oscillations in vitro.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Role of neural oscillations in depression: highlights on gamma oscillations.Translational psychiatry · 2026Review
- Neuroplastic effects of transcranial alternating current stimulation (tACS): from mechanisms to clinical trials.Frontiers in human neuroscience · 2025Review
- Neural Synchrony and Network Dynamics in Social Interaction: A Hyper-Brain Cell Assembly Hypothesis.Frontiers in human neuroscience · 2022Article
- Expanding our understanding of sensory gating in children with autism spectrum disorders.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- Prepulse Inhibition of Auditory Cortical Responses in the Caudolateral Superior Temporal Gyrus in Macaca mulatta.Neuroscience bulletin · 2018Article
- Effects of Stimulus-Driven and Goal-Directed Attention on Prepulse Inhibition of Brain Oscillations.Frontiers in human neuroscience · 2016Article
- Dopaminergic and cholinergic modulation of striatal tyrosine hydroxylase interneurons.Neuropharmacology · 2015Article
- Article
- Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia.Neuropsychiatric disease and treatment · 2014Review
- Evidence for gamma and beta sensory gating deficits as translational endophenotypes for schizophrenia.Psychiatry research · 2013Article
- M-type channels selectively control bursting in rat dopaminergic neurons.The European journal of neuroscience · 2010Article
- Somatosensory-related gamma-, beta- and alpha-augmentation precedes alpha- and beta-attenuation in humans.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2010Article
- Event-related potential abnormalities in schizophrenia: a failure to "gate in" salient information?Schizophrenia research · 2009Article
- Sub-Millisecond Firing Synchrony of Closely Neighboring Pyramidal Neurons in Hippocampal CA1 of Rats During Delayed Non-Matching to Sample Task.Frontiers in neural circuits · 2009Article
- Neurophysiological endophenotypes across bipolar and schizophrenia psychosis.Schizophrenia bulletin · 2008Review
- A novel multiple objective optimization framework for constraining conductance-based neuron models by experimental data.Frontiers in neuroscience · 2007Article
- Synapse-specific mGluR1-dependent long-term potentiation in interneurones regulates mouse hippocampal inhibition.The Journal of physiology · 2004Article
- Two forms of electrical resonance at theta frequencies, generated by M-current, h-current and persistent Na+ current in rat hippocampal pyramidal cells.The Journal of physiology · 2002Article
- Neural Activity Patterns Underlying Spatial Coding in the Hippocampus.Current topics in behavioral neurosciencesReview
- Analysis of state-dependent transitions in frequency and long-distance coordination in a model oscillatory cortical circuit.Journal of computational neuroscienceArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
gamma (30-70 Hz) followed by beta (10-30 Hz) oscillations are evoked in humans by sensory stimuli and may be involved in working memory. Phenomenologically similar gamma-->beta oscillations can be evoked in hippocampal slices by strong two-site tetanic stimulation. Weaker stimulation leads only to two-site synchronized gamma. In vitro oscillations have memory-like features: (1) EPSPs increase during gamma-->beta; (2) after a strong one-site stimulus, two-site stimulation produces desynchronized gamma; and (3) a single synchronized gamma-->beta epoch allows a subsequent weak stimulus to induce synchronized gamma-->beta. Features 2 and 3 last >50 min and so are unlikely to be caused by presynaptic effects. A previous model replicated the gamma-->beta transition when it was assumed that K(+) conductance(s) increases and there is an ad hoc increase in pyramidal EPSCs. Here, we have refined the model, so that both pyramidal-->pyramidal and pyramidal-->interneuron synapses are modifiable. This model, in a self-organized way, replicates the gamma-->beta transition, along with features 1 and 2 above. Feature 3 is replicated if learning rates, or the time course of K(+) current block, are graded with stimulus intensity. Synaptic plasticity allows simulated oscillations to synchronize between sites separated by axon conduction delays over 10 msec. Our data suggest that one function of gamma oscillations is to permit synaptic plasticity, which is then expressed in the form of beta oscillations. We propose that the period of gamma oscillations, approximately 25 msec, is "designed" to match the time course of [Ca(2+)](i) fluctuations in dendrites, thus facilitating learning.
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Identifiers
11698616PMC6762263What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.