ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Sorting of internalized neurotrophins into an endocytic transcytosis pathway via the Golgi system: Ultrastructural analysis in retinal ganglion cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 82 citations in OpenAlex.
- Mechanisms Controlling the Expression and Secretion of BDNF.Biomolecules · 2023Review
- Brain-Derived Neurotrophic Factor-Mediated Neuroprotection in Glaucoma: A Review of Current State of the Art.Frontiers in pharmacology · 2022Review
- The physiology of regulated BDNF release.Cell and tissue research · 2020Review
- Muscle regulates mTOR dependent axonal local translation in motor neurons via CTRP3 secretion: implications for a neuromuscular disorder, spinal muscular atrophy.Acta neuropathologica communications · 2019Article
- A zwitterionic near-infrared dye linked TrkC targeting agent for imaging metastatic breast cancer.MedChemComm · 2018Article
- Signaling Over Distances.Molecular & cellular proteomics : MCP · 2016Review
- Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling.Molecular and cellular neurosciences · 2016Article
- Targeted PDT agent eradicates TrkC expressing tumors via photodynamic therapy (PDT).Molecular pharmaceutics · 2015Article
- Double-targeting using a TrkC ligand conjugated to dipyrrometheneboron difluoride (BODIPY) based photodynamic therapy (PDT) agent.Journal of medicinal chemistry · 2013Article
- Anterograde trafficking of neurotrophin-3 in the adult olfactory system in vivo.Experimental neurology · 2013Article
- Small Molecule Ligands For Active Targeting Of TrkC-expressing Tumor Cells.ACS medicinal chemistry letters · 2012Article
- Functional characterization and axonal transport of quantum dot labeled BDNF.Integrative biology : quantitative biosciences from nano to macro · 2012Article
- Insights into the roles of local translation from the axonal transcriptome.Open biology · 2012Review
- Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The locus ceruleus responds to signaling molecules obtained from the CSF by transfer through tanycytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing.The Journal of biological chemistry · 2011Article
- Multivesicular bodies in neurons: distribution, protein content, and trafficking functions.Progress in neurobiology · 2011Review
- Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release.The Journal of biological chemistry · 2010Article
- Fates of neurotrophins after retrograde axonal transport: phosphorylation of p75NTR is a sorting signal for delayed degradation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Role of the brain-derived neurotrophic factor at glutamatergic synapses.British journal of pharmacology · 2008Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Subcellular pathways and accumulation of internalized radiolabeled neurotrophins NGF, BDNF, and NT-3 were examined in retinal ganglion cells (RGCs) of chick embryos by using quantitative electron microscopic autoradiography. All three neurotrophins accumulated in endosomes and multivesicular bodies. BDNF and NGF also concentrated at the plasma membrane, whereas NT-3 accumulated transiently in the Golgi system. The enhanced targeting of NT-3 to the Golgi system correlated with the anterograde axonal transport of this neurotrophin. Anterograde transport of NT-3, but not its internalization, was significantly attenuated by the tyrosine kinase (trk) inhibitor K252a. Abolishment of trk activity with K252a shifted NT-3 (and BDNF) away from the Golgi system and into a lysosomal pathway, indicating that trk activity regulated sorting of the ligand-receptor complex. Cross-linking of neurotrophins and immunoprecipitation with antibodies to the neurotrophin receptors p75, trkA, trkB, and trkC showed that the large majority of exogenous, receptor-bound NT-3 was bound to trkC in RGC somata, but during anterograde transport in the optic nerve most receptor-bound NT-3 was associated with p75, and after arrival and release in the optic tectum transferred to presumably postsynaptic trkC. These results reveal remarkable and unexpected differences in the intracellular pathways and fates of different neurotrophins within the same cell type. They provide first evidence for an endocytic pathway of internalized neurotrophic factors via the Golgi system before anterograde transport and transcytosis. The results challenge the belief that after internalization all neurotrophins are rapidly degraded in lysosomes.
Indexed as
Identifiers
11698603PMC6762282W2124054304What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.