ArticleJournal of bacteriology2001
The default state of the membrane-localized histidine kinase PrrB of Rhodobacter sphaeroides 2.4.1 is in the kinase-positive mode.
Article in Journal of bacteriology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Enhanced PrrAB system activation and restricted farnesyl pyrophosphate diversion underlie high coenzyme QSynthetic and systems biotechnology · 2026Article
- High-yield porphyrin production through metabolic engineering and biocatalysis.Nature biotechnology · 2025Article
- RegA Plays a Key Role in Oxygen-Dependent Establishment of Persistence and in Isocitrate Lyase Activity, a Critical Determinant ofFrontiers in cellular and infection microbiology · 2017Article
- Bacterial adaptation of respiration from oxic to microoxic and anoxic conditions: redox control.Antioxidants & redox signaling · 2012Review
- Half-Site DNA sequence and spacing length contributions to PrrA binding to PrrA site 2 of RSP3361 in Rhodobacter sphaeroides 2.4.1.Journal of bacteriology · 2009Article
- In vivo sensitivity of blue-light-dependent signaling mediated by AppA/PpsR or PrrB/PrrA in Rhodobacter sphaeroides.Journal of bacteriology · 2009Article
- Regulation of the Rhodobacter sphaeroides 2.4.1 hemA gene by PrrA and FnrL.Journal of bacteriology · 2008Article
- Dominant role of the cbb3 oxidase in regulation of photosynthesis gene expression through the PrrBA system in Rhodobacter sphaeroides 2.4.1.Journal of bacteriology · 2007Article
- Development of the bacterial photosynthetic apparatus.Current opinion in microbiology · 2006Review
- Identification of a ubiquinone-binding site that affects autophosphorylation of the sensor kinase RegB.The Journal of biological chemistry · 2006Article
- RegB/RegA, a highly conserved redox-responding global two-component regulatory system.Microbiology and molecular biology reviews : MMBR · 2004Review
- Mutational analysis of the signal-sensing domain of ResE histidine kinase from Bacillus subtilis.Journal of bacteriology · 2004Article
- Involvement of the PrrB/PrrA two-component system in nitrite respiration in Rhodobacter sphaeroides 2.4.3: evidence for transcriptional regulation.Journal of bacteriology · 2002Article
- Photosynthesis genes and their expression in Rhodobacter sphaeroides 2.4.1: a tribute to my students and associates.Photosynthesis research · 2002Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The PrrBA two-component activation system of Rhodobacter sphaeroides plays a major role in the induction of photosynthesis gene expression under oxygen-limiting or anaerobic conditions. The PrrB histidine kinase is composed of two structurally identifiable regions, the conserved C-terminal kinase/phosphatase domain and the N-terminal membrane-spanning domain with six transmembrane helices framing three periplasmic and two cytoplasmic loops. Using a set of PrrB mutants with lesions in the transmembrane domain, we demonstrate that the central portion of the PrrB transmembrane domain including the second periplasmic loop plays an important role in both sensing and signal transduction. Signal transduction via the transmembrane domain is ultimately manifested by controlling the activity of the C-terminal kinase/phosphatase domain. The extent of signal transduction is determined by the ability of the transmembrane domain to sense the strength of the inhibitory signal received from the cbb(3) terminal oxidase (J.-I Oh, and S. Kaplan, EMBO J. 19:4237-4247, 2000). Therefore, the intrinsic ("default") state of PrrB is in the kinase-dominant mode. It is also demonstrated that the extent of prrB gene expression is subject to the negative autoregulation of the PrrBA system.
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Registered trials
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