ArticleThe Journal of experimental medicine2001
Tumor necrosis factor-dependent segmental control of MIG expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitment.
Article in The Journal of experimental medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 173 citations in OpenAlex.
- Regulation, Maintenance, and Remodeling of High Endothelial Venules in Homeostasis, Inflammation, and Cancer.Current opinion in physiology · 2023Article
- Lessons of Vascular Specialization From Secondary Lymphoid Organ Lymphatic Endothelial Cells.Circulation research · 2023Review
- Proteomic analysis of serum in workers exposed to diesel engine exhaust.Environmental and molecular mutagenesis · 2022Article
- A Teleost CXCL10 Is Both an Immunoregulator and an Antimicrobial.Frontiers in immunology · 2022Article
- High endothelial venules (HEVs) in immunity, inflammation and cancer.Angiogenesis · 2021Review
- Overcoming physiological barriers by nanoparticles for intravenous drug delivery to the lymph nodes.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- In Sickness and in Health: The Immunological Roles of the Lymphatic System.International journal of molecular sciences · 2021Review
- High Endothelial Venules: A Vascular Perspective on Tertiary Lymphoid Structures in Cancer.Frontiers in immunology · 2021Review
- Prostate Epithelial RON Signaling Promotes M2 Macrophage Activation to Drive Prostate Tumor Growth and Progression.Molecular cancer research : MCR · 2020Article
- A molecular map of murine lymph node blood vascular endothelium at single cell resolution.Nature communications · 2020Article
- Article
- A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature.Frontiers in cardiovascular medicine · 2020Article
- High endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer.British journal of cancer · 2019Article
- Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL-33/ST2 signaling axis.Clinical science (London, England : 1979) · 2019Article
- Inhibitory Effect ofInternational journal of molecular sciences · 2018Article
- Migratory Dendritic Cells, Group 1 Innate Lymphoid Cells, and Inflammatory Monocytes Collaborate to Recruit NK Cells to the Virus-Infected Lymph Node.Cell reports · 2018Article
- Article
- Understanding high endothelial venules: Lessons for cancer immunology.Oncoimmunology · 2015Review
- CXCL10 induces the recruitment of monocyte-derived macrophages into kidney, which aggravate puromycin aminonucleoside nephrosis.Clinical and experimental immunology · 2015Article
- The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection.Disease models & mechanisms · 2015Article
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5 authors.
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Abstract
Monocytes recruited from the blood are key contributors to the nature of an immune response. While monocyte recruitment in a subset of immunopathologies has been well studied and largely attributed to the chemokine monocyte chemoattractant protein (MCP)-1, mechanisms mediating such recruitment to other sites of inflammation remain elusive. Here, we showed that localized inflammation resulted in an increased binding of monocytes to perifollicular high endothelial venules (HEVs) of lymph nodes draining a local inflammatory site. Quantitative PCR analyses revealed the upregulation of many chemokines in the inflamed lymph node, including MCP-1 and MIG. HEVs did not express detectable levels of MCP-1; however, a subset of HEVs in inflamed lymph nodes in wild-type (but not tumor necrosis factor [TNF] null mice) expressed MIG and this subset of HEVs preferentially supported monocyte binding. Expression of CXCR3, the receptor for MIG, was detected on a small subset of peripheral blood monocytes and on a significant percentage of recruited monocytes. Most importantly, in both ex vivo and in vivo assays, neutralizing anti-MIG antibodies blocked monocyte binding to inflamed lymph node HEVs. Together, these results suggest that the lymph node microenvironment can dictate the nature of molecules expressed on HEV subsets in a TNF-dependent fashion and that inflammation-induced MIG expression by HEVs can mediate monocyte recruitment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.