ArticleThe Journal of experimental medicine2001
Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes.
Article in The Journal of experimental medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 107 citations in OpenAlex.
- Gut mucosal immune responses - Implications for celiac disease and food allergy.Seminars in immunology · 2025Review
- Somatic hypermutation generates antibody specificities beyond the primary repertoire.Immunity · 2025Article
- Oral tolerance to dietary antigens and Foxp3Immunological reviews · 2024Review
- Mechanical loading of joint modulates T cells in lymph nodes to regulate osteoarthritis.Osteoarthritis and cartilage · 2024Article
- Current Status on Immunological Therapies for Type 1 Diabetes Mellitus.Current diabetes reports · 2019Review
- Microbial symbionts regulate the primary Ig repertoire.The Journal of experimental medicine · 2018Article
- Stochasticity enables BCR-independent germinal center initiation and antibody affinity maturation.The Journal of experimental medicine · 2018Article
- IgG1 memory B cells keep the memory of IgE responses.Nature communications · 2017Article
- B Cell Intrinsic Mechanisms Constraining IgE Memory.Frontiers in immunology · 2017Review
- Regulatory T cells in allergic diseases.The Journal of allergy and clinical immunology · 2016Review
- A subpopulation of high IL-21-producing CD4(+) T cells in Peyer's Patches is induced by the microbiota and regulates germinal centers.Scientific reports · 2016Article
- Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus.Nature communications · 2016Article
- Antiallergic Effects of Trichostatin A in a Murine Model of Allergic Rhinitis.Clinical and experimental otorhinolaryngology · 2015Article
- The Extracellular Domains of IgG1 and T Cell-Derived IL-4/IL-13 Are Critical for the Polyclonal Memory IgE Response In Vivo.PLoS biology · 2015Article
- The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response.The Journal of experimental medicine · 2013Article
- Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells.The Journal of experimental medicine · 2012Article
- Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Sequential class switching is required for the generation of high affinity IgE antibodies.The Journal of experimental medicine · 2012Article
- Regulatory T cells in radiotherapeutic responses.Frontiers in oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A key event in the pathogenesis of allergies is the production of antibodies of the immunoglobulin (Ig)E class. In normal individuals the levels of IgE are tightly regulated, as illustrated by the low serum IgE concentration. In addition, multiple immunizations are usually required to generate detectable IgE responses in normal experimental animals. To define the parameters that regulate IgE production in vivo, we generated mice bearing monoclonal populations of B and T lymphocytes specific for influenza virus hemagglutinin (HA) and chicken ovalbumin (OVA), respectively. A single immunization of the monoclonal mice with the cross-linked OVA-HA antigen led to serum IgE levels that reached 30-200 microg/ml. This unusually high IgE response was prevented by the infusion of regulatory alpha/beta CD4(+) T cells belonging to both CD25(+) and CD25(-) subpopulations. The regulation by the infused T cells impeded the development of fully competent OVA-specific effector/memory Th2 lymphocytes without inhibiting the initial proliferative response of T cells or promoting activation-induced cell death. Our results indicate that hyper IgE responses do not occur in normal individuals due to the presence of regulatory T cells, and imply that the induction of regulatory CD4(+) T cells could be used for the prevention of atopy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.