ArticleThe American journal of pathology2001
Exposure of mice to topical bovine thrombin induces systemic autoimmunity.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- Angiogenesis is critical for the exercise-mediated enhancement of axon regeneration following peripheral nerve injury.Experimental neurology · 2022Article
- Advantages of Fibrin Polymerization Method without the Use of Exogenous Thrombin for Vascular Tissue Engineering Applications.Biomedicines · 2022Article
- Sciatic Nerve Cut and Repair Using Fibrin Glue in Adult Mice.Bio-protocol · 2019Article
- Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function.Frontiers in immunology · 2019Article
- Evaluation of the effect of calcium gluconate and bovine thrombin on the temporal release of transforming growth factor beta 1 and platelet-derived growth factor isoform BB from feline platelet concentrates.BMC veterinary research · 2012Article
- The potential for salmon fibrin and thrombin to mitigate pain subsequent to cervical nerve root injury.Biomaterials · 2011Article
- Thrombin use in surgery: an evidence-based review of its clinical use.Journal of blood medicine · 2010Article
- Soft materials to treat central nervous system injuries: evaluation of the suitability of non-mammalian fibrin gels.Biochimica et biophysica acta · 2009Review
- Clinical use of topical thrombin as a surgical hemostat.Biologics : targets & therapy · 2008Article
- Estimating the pathogen safety of manufactured human plasma products: application to fibrin sealants and to thrombin.Transfusion · 2008Article
- Protease-activated receptor-2 signaling triggers dendritic cell development.The American journal of pathology · 2003Article
- Bovine thrombin and systemic autoimmunity.The American journal of pathology · 2003Article
- Immunological consequences of topical bovine thrombin.The American journal of pathology · 2001Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine thrombin is used as an aid to hemostasis in medical and surgical procedures. At least 500,000 Americans are exposed to this therapeutic annually and reports suggest that exposure is associated with the development of autoreactive antibodies. To determine whether bovine thrombin can induce pathological autoimmunity we exposed nonautoimmune-prone galactose-alpha1-3-galactose-deficient mice to the two bovine thrombin preparations currently approved for use in the United States. We found that, like humans exposed to bovine thrombin, mice developed an immune response against the therapeutic and the xenogeneic carbohydrate galactose-alpha1-3-galactose, and some mice developed autoantibodies against clotting factors. Further, unexpectedly, a single exposure to this therapeutic also induced autoimmunity with features characteristic of systemic lupus erythematosus including antibodies against nuclear antigens, native DNA, double-stranded DNA, and cardiolipin. High levels of these autoantibodies correlated with glomerulonephritis in all mice evaluated. This autoimmune syndrome was detected in mice 15 weeks after a secondary exposure to bovine thrombin and female mice were found to develop the syndrome at a significantly greater frequency than males. Thus, these studies indicate that exposure to bovine thrombin preparations can induce a pathological systemic autoimmune syndrome with lupus-like serology.
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