ArticleThe American journal of pathology2001
Regulation of telomerase activity by alternate splicing of human telomerase reverse transcriptase mRNA in a subset of neuroblastomas.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461.Journal of experimental & clinical cancer research : CR · 2018Article
- Changes in telomerase activity due to alternative splicing of human telomerase reverse transcriptase in colorectal cancer.Oncology letters · 2017Article
- Article
- Expression Pattern of Alternative Splicing Variants of Human Telomerase Reverse Transcriptase (hTERT) in Cancer Cell Lines Was not Associated with the Origin of the Cells.International journal of molecular and cellular medicine · 2015Article
- Colony forming unit endothelial cells do not exhibit telomerase alternative splicing variants and activity.Iranian biomedical journal · 2013Article
- Human telomerase activity regulation.Molecular biology reports · 2011Review
- Quantification of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the beta deletion variant.Neoplasia (New York, N.Y.) · 2008Article
- Integrated nanosensors to determine levels and functional activity of human telomerase.Neoplasia (New York, N.Y.) · 2008Article
- Article
- Sclerosing pseudovascular rhabdomyosarcoma-immunohistochemical, ultrastructural, and genetic findings indicating a distinct subtype of rhabdomyosarcoma.Virchows Archiv : an international journal of pathology · 2006Article
- Telomerase gene expression in the chicken: Telomerase RNA (TR) and reverse transcriptase (TERT) transcript profiles are tissue-specific and correlate with telomerase activity.Age (Dordrecht, Netherlands) · 2005Article
- [Proliferation and hTERT expression in neuroblastoma].Der Pathologe · 2004Article
- Expression of the c-kit receptor characterizes a subset of neuroblastomas with favorable prognosis.Oncogene · 2004Article
- Telomerase activity in B-cell non-Hodgkin lymphomas is regulated by hTERT transcription and correlated with telomere-binding protein expression but uncoupled from proliferation.British journal of cancer · 2003Article
- Full-length telomerase reverse transcriptase messenger RNA is an independent prognostic factor in neuroblastoma.The American journal of pathology · 2003Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been proposed that the regulation of telomerase takes place at the transcriptional level, the expression of the catalytic subunit human telomerase reverse transcriptase (hTERT) being crucial for telomerase activity (TA). Recently, differential splicing of hTERT mRNA has been demonstrated in various tissues during embryonal development, and it has been suggested that only full-length transcripts translate into functionally active telomerase. With this in view, we analyzed the different hTERT transcripts by reverse transcriptase-polymerase chain reaction in neuroblastic tumors and compared the results with the TA, the tumor growth fraction, and the MYCN status. In a series of 38 neuroblastic tumors, high TA and full-length hTERT transcripts were found in nine samples, whereas nine samples showed absence of both enzymatic activity and hTERT transcripts. Interestingly, in another eight samples, low or absent TA coincided with a lack of full-length hTERT transcripts. Eleven samples contained hTERT transcripts with low or undetectable TA and one sample had low TA but no hTERT transcripts. TA correlated with MYCN amplification and was weakly associated with the proliferative activity. Moreover, a significant correlation with tumor progression was observed. Our findings point at a posttranscriptional regulation of TA in a subset of neuroblastic tumors. Because high TA was detected only in tumors with full-length hTERT transcripts, reverse transcriptase-polymerase chain reaction analysis of archival neuroblastic tumor samples might help to appraise the malignant potential in individual cases.
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