ArticleThe American journal of pathology2001
Expression of the T-cell chemoattractant chemokine lymphotactin in Crohn's disease.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- The role of tacrolimus in inflammatory bowel disease: a systematic review.Digestive diseases and sciences · 2006Pooled it
- Identification of the key genes in children with sepsis by WGCNA in multiple GEO datasets.Frontiers in pediatrics · 2025Article
- Traumatic brain injury in mice induces changes in the expression of the XCL1/XCR1 and XCL1/ITGA9 axes.Pharmacological reports : PR · 2020Article
- Blockade of XCL1/Lymphotactin Ameliorates Severity of Periprosthetic Osteolysis Triggered by Polyethylene-Particles.Frontiers in immunology · 2020Article
- A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal Neuronal Excitability.Neuroscience · 2018Article
- Modulation of immunogenicity and immunoprotection of mucosal vaccine against coxsackievirus B3 by optimizing the coadministration mode of lymphotactin adjuvant.DNA and cell biology · 2012Article
- Differential cytokine responses in human and mouse lymphatic endothelial cells to cytokines in vitro.Lymphatic research and biology · 2010Article
- Neutralizing endogenous chemokines with small molecules. Principles and potential therapeutic applications.Pharmacology & therapeutics · 2010Review
- Intestinal bacteria and the regulation of immune cell homeostasis.Annual review of immunology · 2010Review
- Chemokine and chemokine receptor expression analysis in target organs of acute graft-versus-host disease.Genes and immunity · 2009Article
- Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis.American journal of respiratory cell and molecular biology · 2009Article
- Article
- Ex vivo expanded dendritic cells home to T-cell zones of lymphoid organs and survive in vivo after allogeneic bone marrow transplantation.The American journal of pathology · 2005Article
- Increased expression of CCL20 in human inflammatory bowel disease.Journal of clinical immunology · 2004Article
- Structural rearrangement of human lymphotactin, a C chemokine, under physiological solution conditions.The Journal of biological chemistry · 2002Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recruitment of lymphocytes is a prominent feature of the inflammatory process in Crohn's disease (CD). The present study was undertaken to investigate the expression of the novel lymphocyte-specific chemoattractant lymphotactin (Lptn) as a potential regulatory factor for the recruitment of T cells in CD. The expression of Lptn mRNA was quantified in resection specimens of patients with CD in comparison to normal controls without signs of inflammation by real-time quantitative reverse transcriptase-polymerase chain reaction and localized by nonradioactive in situ hybridization. Furthermore, the phenotype of cells expressing Lptn mRNA was characterized. In contrast to normal controls Lptn mRNA was significantly increased in tissue samples affected by CD. Cells expressing Lptn were identified as T cells, mast cells, and unexpectedly dendritic cells. Lptn mRNA was found to be up-regulated on stimulation with phorbol-12-myristate-13-acetate and concanavalin A in T cells isolated from peripheral blood, which could be prevented by dexamethasone, cyclosporine A, and FK506. A similar regulation mechanism could be identified for the Lptn receptor GPR-5 in peripheral T cells. In addition, Lptn mRNA expression could be induced in mature monocyte-derived dendritic cells. The results indicate that local expression of Lptn by activated T cells and to a lesser extent by mast cells and dendritic cells represents a key regulator for lymphocyte trafficking and maintenance of the inflammatory process observed in CD, which might be partly mediated through an autocrine/paracrine pathway of activated T cells.
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