ArticleThe American journal of pathology2001
The distribution and regulation of integrin-linked kinase in normal and diabetic kidneys.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 84 citations in OpenAlex.
- Biochemical composition of the glomerular extracellular matrix in patients with diabetic kidney disease.World journal of diabetes · 2022Review
- Article
- Integrin-Linked Kinase Deficiency in Collecting Duct Principal Cell Promotes Necroptosis of Principal Cell and Contributes to Kidney Inflammation and Fibrosis.Journal of the American Society of Nephrology : JASN · 2019Article
- Rethinking glomerular basement membrane thickening in diabetic nephropathy: adaptive or pathogenic?American journal of physiology. Renal physiology · 2016Review
- Echistatin prevents posterior capsule opacification in diabetic rabbit model via integrin linked kinase signaling pathway.International journal of clinical and experimental pathology · 2015Article
- Benazepril affects integrin-linked kinase and smooth muscle α-actin expression in diabetic rat glomerulus and cultured mesangial cells.BMC nephrology · 2014Article
- Shiga toxin promotes podocyte injury in experimental hemolytic uremic syndrome via activation of the alternative pathway of complement.Journal of the American Society of Nephrology : JASN · 2014Article
- The importance of podocyte adhesion for a healthy glomerulus.Frontiers in endocrinology · 2014Review
- Cell-matrix adhesion of podocytes in physiology and disease.Nature reviews. Nephrology · 2013Review
- The glomerular podocyte as a target of growth hormone action: implications for the pathogenesis of diabetic nephropathy.Current diabetes reviews · 2011Review
- Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria.Kidney international · 2010Article
- Interaction of integrin-linked kinase and miniature chromosome maintenance 7-mediating integrin {alpha}7 induced cell growth suppression.Cancer research · 2010Article
- New insights into epithelial-mesenchymal transition in kidney fibrosis.Journal of the American Society of Nephrology : JASN · 2010Review
- Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism.Journal of cellular physiology · 2010Article
- Abnormalities in signaling pathways in diabetic nephropathy.Expert review of endocrinology & metabolism · 2010Article
- Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis.Journal of the American Society of Nephrology : JASN · 2009Article
- Roles of PINCH-2 in regulation of glomerular cell shape change and fibronectin matrix deposition.American journal of physiology. Renal physiology · 2008Article
- Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling.The Journal of clinical investigation · 2007Article
- Up-regulation of integrin-linked kinase in the streptozotocin-induced diabetic rat retina.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2007Article
- The parvins.Cellular and molecular life sciences : CMLS · 2006Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Alteration in cell adhesion and extracellular matrix deposition is a hallmark of diabetic glomerulosclerosis. Integrin-linked kinase (ILK) is a recently identified integrin cytoplasmic-binding protein that has been implicated in the regulation of cell adhesion and extracellular matrix deposition. To begin to investigate whether ILK is involved in the pathogenesis of diabetic glomerulosclerosis, we have analyzed the distribution and regulation of ILK in normal and diabetic kidneys as well as in isolated mesangial cells. We have found that ILK is normally expressed at high concentration in visceral epithelial cells. In diabetic glomeruli, ILK expression in the mesangium is dramatically increased. The increase in ILK level is associated with diffuse mesangial expansion. In glomeruli where advanced nodular sclerosis and global sclerosis were dominant, ILK level was reduced, suggesting that the increase in ILK expression likely associates with relatively early glomerulosclerosis. Additionally, we have found that exposure of mesangial cells to high concentrations of glucose significantly increased the ILK level. Finally, we show that ILK localizes to regions of cell membranes that are in close contact with mesangial fibronectin matrix. These results suggest that ILK is likely involved in mesangial matrix expansion in response to hyperglycemia in the pathogenesis of diabetic glomerulosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.