ArticleThe Biochemical journal2001
Interleukin-10 up-regulates tumour-necrosis-factor-alpha-related apoptosis-inducing ligand (TRAIL) gene expression in mammary epithelial cells at the involution stage.
Article in The Biochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 32 citations in OpenAlex.
- Temporal trends in the inflammatory cytokine profile of human breastmilk.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2014Article
- Mammary gland involution as an immunotherapeutic target for postpartum breast cancer.Journal of mammary gland biology and neoplasia · 2014Review
- Proliferative, structural and molecular features of the Mdx mouse prostate.International journal of experimental pathology · 2010Article
- Regulation of ERalpha-mediated transcription of Bcl-2 by PI3K-AKT crosstalk: implications for breast cancer cell survival.International journal of oncology · 2010Article
- Evolution on experimental animal model for upper urothelium carcinogenesis.World journal of urology · 2010Article
- The contribution of dynamic stromal remodeling during mammary development to breast carcinogenesis.Breast cancer research : BCR · 2010Review
- Mammary involution and breast cancer risk: transgenic models and clinical studies.Journal of mammary gland biology and neoplasia · 2009Review
- Apoptosis regulation in the mammary gland.Cellular and molecular life sciences : CMLS · 2004Review
- Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression.Breast cancer research : BCR · 2004Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although interleukin-10 (IL-10) is known to contribute to inflammation and pathogenesis in mammalian organs, little is known about its precise role in the mammary gland. We found that IL-10 levels fluctuated during the mouse mammary cycle, showing little expression at the lactation stage and the highest expression at the involution stage. To reveal the effects of IL-10 on involution, expression profiles of apoptosis-related genes were examined in mice transgenic for IL-10 as well as in IL-10(-/-) mice. Mild inflammatory lesions by lymphocytes were observed in the mammary glands from four of seven transgenic lines at the lactation stage. It was striking that the expression of tumour-necrosis-factor-alpha-related apoptosis-inducing ligand (TRAIL) among the apoptosis-related genes was elevated approx. 7-fold in the transgenic mice, whereas others were almost unchanged. Furthermore, TRAIL was down-regulated 4-fold in the IL-10(-/-) mice at the involution stage. Elevated expression of TRAIL and of death receptor 4 (DR4) protein was identified at the involution stage of normal mammary glands as well as at the lactation stage of the IL-10 transgenic mice. These results indicate that the elevated expression of IL-10 at the involution stage recruits lymphocytes and induces the expression of TRAIL and DR4. These phenomena might partly contribute to apoptosis in the mammary epithelial cells for entering involution.
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