ArticleMolecular biology of the cell2001
Rab4 regulates formation of synaptic-like microvesicles from early endosomes in PC12 cells.
Article in Molecular biology of the cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Phosphatidylinositol-3-phosphate-dependent Klp98A recruitment regulates endosomal flux underlying developmental synaptic remodeling via Rab4.Journal of cell science · 2026Article
- Assessing the Potential of NGF-Differentiated PC12 Cells as a Model for Synaptic Transmission.Molecular neurobiology · 2025Article
- Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry.International journal of molecular sciences · 2024Article
- Receptor-mediated internalization promotes increased endosome size and number in a RAB4- and RAB5-dependent manner.European journal of cell biology · 2023Article
- Drosophila transmembrane protein 214 (dTMEM214) regulates midgut glucose uptake and systemic glucose homeostasis.Developmental biology · 2023Article
- Integrating intracellular nanovesicles into integrin trafficking pathways and beyond.Cellular and molecular life sciences : CMLS · 2022Review
- MON2 Guides Wntless Transport to the Golgi through Recycling Endosomes.Cell structure and function · 2020Article
- AP-2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons.EMBO reports · 2020Article
- Rab GTPases: Switching to Human Diseases.Cells · 2019Review
- Local protein dynamics during microvesicle exocytosis in neuroendocrine cells.Molecular biology of the cell · 2018Article
- Rab GTPases and Membrane Trafficking in Neurodegeneration.Current biology : CB · 2018Review
- Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions.Nature communications · 2018Article
- Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of myosin II.Molecular biology of the cell · 2014Article
- Rab5 and Rab4 regulate axon elongation in the Xenopus visual system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a.Traffic (Copenhagen, Denmark) · 2012Article
- Article
- The ubiquitin ligase HACE1 regulates Golgi membrane dynamics during the cell cycle.Nature communications · 2011Article
- Important relationships between Rab and MICAL proteins in endocytic trafficking.World journal of biological chemistry · 2010Article
- Spatial cycles in G-protein crowd control.The EMBO journal · 2010Review
- Functional cross-talk between Rab14 and Rab4 through a dual effector, RUFY1/Rabip4.Molecular biology of the cell · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Early endosomes in PC12 cells are an important site for the formation of synaptic-like microvesicles and constitutive recycling vesicles. By immunogold electron microscopy, the small GTPase rab4 was localized to early endosomes and numerous small vesicles in the cell periphery and Golgi area of PC12 cells. Overexpression of GTPase-deficient Q67Lrab4 increased the number of early endosome-associated and cytoplasmic vesicles, whereas expression of GDP-bound S22Nrab4 significantly increased the length of early endosomal tubules. In parallel, Q67Lrab4 induced a shift in rab4, VAMP2, and TfR label from early endosomes to peripheral vesicles, whereas S22Nrab4 increased early endosome labeling of all three proteins. These observations were corroborated by early endosome budding assays. Together, our data document a thus far unrecognized role for rab4 in the formation of synaptic-like microvesicles and add to our understanding of the formation of constitutive recycling vesicles from early endosomes.
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