ArticleMolecular biology of the cell2001
The target of rapamycin signaling pathway regulates mRNA turnover in the yeast Saccharomyces cerevisiae.
Article in Molecular biology of the cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 60 citations in OpenAlex.
- The Central FacilitaTOR: Coordinating Transcription and Translation in Eukaryotes.International journal of molecular sciences · 2025Review
- Review
- The RNA Helicase Ded1 Regulates Translation and Granule Formation during Multiple Phases of Cellular Stress Responses.Molecular and cellular biology · 2022Article
- Translational control by helicases during cellular stress.Methods in enzymology · 2022Article
- Article
- Alterations of signaling pathways in response to chemical perturbations used to measure mRNA decay rates in yeast.RNA (New York, N.Y.) · 2020Article
- Protein Kinases at the Intersection of Translation and Virulence.Frontiers in cellular and infection microbiology · 2019Review
- An mRNA decapping mutant deficient in P body assembly limits mRNA stabilization in response to osmotic stress.Scientific reports · 2017Article
- mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation.Cell cycle (Georgetown, Tex.) · 2016Article
- Steady-state and dynamic gene expression programs in Saccharomyces cerevisiae in response to variation in environmental nitrogen.Molecular biology of the cell · 2016Article
- Mammalian Target of Rapamycin (mTOR) Tagging Promotes Dendritic Branch Variability through the Capture of Ca2+/Calmodulin-dependent Protein Kinase II α (CaMKIIα) mRNAs by the RNA-binding Protein HuD.The Journal of biological chemistry · 2015Article
- Crosstalk between Edc4 and mammalian target of rapamycin complex 1 (mTORC1) signaling in mRNA decapping.International journal of molecular sciences · 2014Article
- Quantification of mRNA stability of stress-responsive yeast genes following conditional excision of open reading frames.RNA biology · 2013Article
- Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1.The Journal of cell biology · 2013Article
- Uncoupling of mRNA synthesis and degradation impairs adaptation to host temperature in Cryptococcus neoformans.Molecular microbiology · 2013Article
- Ornithine decarboxylase mRNA is stabilized in an mTORC1-dependent manner in Ras-transformed cells.The Biochemical journal · 2012Article
- Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress.Cellular signalling · 2012Article
- Review
- The 2',3'-cAMP-adenosine pathway.American journal of physiology. Renal physiology · 2011Review
- 2',3'-cAMP, 3'-AMP, and 2'-AMP inhibit human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors.American journal of physiology. Heart and circulatory physiology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The target of rapamycin (TOR) signaling pathway is an important mechanism by which cell growth is regulated by nutrient availability in eukaryotes. We provide evidence that the TOR signaling pathway controls mRNA turnover in Saccharomyces cerevisiae. During nutrient limitation (diauxic shift) or after treatment with rapamycin (a specific inhibitor of TOR), multiple mRNAs were destabilized, whereas the decay of other mRNAs was unaffected. Our findings suggest that the regulation of mRNA decay by the TOR pathway may play a significant role in controlling gene expression in response to nutrient depletion. The inhibition of the TOR pathway accelerated the major mRNA decay mechanism in yeast, the deadenylation-dependent decapping pathway. Of the destabilized mRNAs, two different responses to rapamycin were observed. Some mRNAs were destabilized rapidly, while others were affected only after prolonged exposure. Our data suggest that the mRNAs that respond rapidly are destabilized because they have short poly(A) tails prematurely either as a result of rapid deadenylation or reduced polyadenylation. In contrast, the mRNAs that respond slowly are destabilized by rapid decapping. In summary, the control of mRNA turnover by the TOR pathway is complex in that it specifically regulates the decay of some mRNAs and not others and that it appears to control decay by multiple mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.