ArticleMolecular biology of the cell2001
Glucocorticoid receptor activation of the I kappa B alpha promoter within chromatin.
Article in Molecular biology of the cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
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- Clinical Use and Molecular Action of Corticosteroids in the Pediatric Age.International journal of molecular sciences · 2019Review
- Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies.PloS one · 2018Article
- REV-ERBα influences the stability and nuclear localization of the glucocorticoid receptor.Journal of cell science · 2016Article
- Involvement of the Androgen and Glucocorticoid Receptors in Bladder Cancer.International journal of endocrinology · 2015Review
- Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1.Cellular and molecular life sciences : CMLS · 2014Article
- Vitamin D analogue TX 527 down-regulates the NF-κB pathway and controls the proliferation of endothelial cells transformed by Kaposi sarcoma herpesvirus.British journal of pharmacology · 2013Article
- Endothelial nuclear lamina is not required for glucocorticoid receptor nuclear import but does affect receptor-mediated transcription activation.American journal of physiology. Cell physiology · 2013Article
- Progesterone receptor induces bcl-x expression through intragenic binding sites favoring RNA polymerase II elongation.Nucleic acids research · 2013Article
- Assaying chromatin structure and remodeling by restriction enzyme accessibility.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases.Endocrine reviews · 2009Review
- Minireview: fetal-maternal hormonal signaling in pregnancy and labor.Molecular endocrinology (Baltimore, Md.) · 2009Review
- Minireview: latest perspectives on antiinflammatory actions of glucocorticoids.Molecular endocrinology (Baltimore, Md.) · 2009Review
- The SWI/SNF chromatin-remodeling complex and glucocorticoid resistance in acute lymphoblastic leukemia.Journal of the National Cancer Institute · 2008Article
- Progesterone receptor inhibits aromatase and inflammatory response pathways in breast cancer cells via ligand-dependent and ligand-independent mechanisms.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Altered histone H1 stoichiometry and an absence of nucleosome positioning on transfected DNA.The Journal of biological chemistry · 2008Article
- Effective transcription factor binding site prediction using a combination of optimization, a genetic algorithm and discriminant analysis to capture distant interactions.BMC bioinformatics · 2007Article
- Periodicity of SNP distribution around transcription start sites.BMC genomics · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The glucocorticoid receptor (GR) is a ligand-activated transcription factor that induces expression of many genes. The GR has been useful for understanding how chromatin structure regulates steroid-induced transcription in model systems. However, the effect of glucocorticoids on chromatin structure has been examined on few endogenous mammalian promoters. We investigated the effect of glucocorticoids on the in vivo chromatin structure of the glucocorticoid-responsive I kappa B alpha gene promoter, the inhibitor of the ubiquitous transcription factor, nuclear factor kappa B (NF kappa B). Glucocorticoids inhibit NF kappa B activity in some tissues by elevating the levels of I kappa B alpha. We found that glucocorticoids activated the I kappa B alpha promoter in human T47D/A1-2 cells containing the GR. We then investigated the chromatin structure of the I kappa B alpha promoter in the absence and presence of glucocorticoids with the use of micrococcal nuclease, restriction enzyme, and deoxyribonuclease (DNaseI) analyses. In untreated cells, the promoter assembles into regularly positioned nucleosomes, and glucocorticoid treatment did not alter nucleosomal position. Restriction enzyme accessiblity studies indicated that the I kappa B alpha promoter is assembled as phased nucleosomes that adopt an "open" chromatin architecture in the absence of hormone. However, glucocorticoids may be required for transcription factor binding, because DNaseI footprinting studies suggested that regulatory factors bind to the promoter upon glucocorticoid treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.