ArticleThe Journal of physiology2001
Ionic basis of the caesium-induced depolarisation in rat supraoptic nucleus neurones.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Taurine release by astrocytes modulates osmosensitive glycine receptor tone and excitability in the adult supraoptic nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Anatomical and electrophysiological comparison of CA1 pyramidal neurons of the rat and mouse.Journal of neurophysiology · 2009Article
- Feedback inhibition of action potential discharge by endogenous adenosine enhancement of the medium afterhyperpolarization.The Journal of physiology · 2009Article
- Oxytocin-induced postinhibitory rebound firing facilitates bursting activity in oxytocin neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Signaling from blood vessels to CNS axons through nitric oxide.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Vasopressin differentially modulates non-NMDA receptors in vasopressin and oxytocin neurons in the supraoptic nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Background and tandem-pore potassium channels in magnocellular neurosecretory cells of the rat supraoptic nucleus.The Journal of physiology · 2003Article
- Flufenamic acid blocks depolarizing afterpotentials and phasic firing in rat supraoptic neurones.The Journal of physiology · 2002Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The effects of external Cs(+) on magnocellular neurosecretory cells were studied during intracellular recordings from 93 supraoptic nucleus neurones in superfused explants of rat hypothalamus. 2. Bath application of 3-5 mM Cs(+) provoked reversible membrane depolarisation and increased firing rate in all of the neurones tested. Voltage-current analysis revealed an increase in membrane resistance between -120 and -55 mV. The increase in resistance was greater below -85 mV than at more positive potentials. 3. Voltage-clamp analysis showed that external Cs(+) blocked the hyperpolarisation-activated inward current, I(H). Under current clamp, application of ZD 7288, a selective blocker of I(H), caused an increase in membrane resistance at voltages < or = -65 mV. Voltage-current analysis further revealed that blockade of I(H) caused hyperpolarisation when the initial voltage was < -60 mV but had no effect at more positive values. 4. Current- and voltage-clamp analysis of the effects of Cs(+) in the presence of ZD 7288, or ZD 7288 and tetraethyl ammonium (TEA), revealed an increase in membrane resistance throughout the range of voltages tested (-120 to -45 mV). The current blocked by Cs(+) in the absence of I(H) was essentially voltage independent and reversed at -100 mV. The reversal potential shifted by +22.7 mV when external [K(+)] was increased from 3 to 9 mM. We conclude that, in addition to blocking I(H), external Cs(+) blocks a leakage K(+) current that contributes significantly to the resting potential of rat magnocellular neurosecretory cells.
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