ArticleThe Journal of physiology2001
Neural components of distension-evoked secretory responses in the guinea-pig distal colon.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 78 citations in OpenAlex.
- Maropitant Citrate Administration Significantly Decreases the Rate of Peristalsis in the Stomach and Jejunum and Does Not Significantly Alter Intestinal Diameter or Intestinal Wall Thickness in Healthy Adult Dogs.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2026Article
- Autonomic neural control of motor activity in the intestine of freshwater barramundi (Lates calcarifer).Cell and tissue research · 2026Article
- Maladaptive sensory coding in the enteric nervous system playing a role in gastrointestinal disorders.Frontiers in cellular neuroscience · 2026Review
- The enteric nervous system.Physiological reviews · 2023Review
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- Cinnamaldehyde Induces Release of Cholecystokinin and Glucagon-Like Peptide 1 by Interacting with Transient Receptor Potential Ankyrin 1 in a Porcine Ex-Vivo Intestinal Segment Model.Animals : an open access journal from MDPI · 2021Article
- Functional circuits and signal processing in the enteric nervous system.Cellular and molecular life sciences : CMLS · 2020Review
- Compression and stretch sensitive submucosal neurons of the porcine and human colon.Scientific reports · 2020Article
- Enteric glia regulate gut motility in health and disease.Brain research bulletin · 2018Review
- Changes in Enteric Neurons of Small Intestine in a Rat Model of Irritable Bowel Syndrome with Diarrhea.Journal of neurogastroenterology and motility · 2016Article
- Mechanosensitive enteric neurons in the guinea pig gastric corpus.Frontiers in cellular neuroscience · 2015Article
- Mechanical stress activates neurites and somata of myenteric neurons.Frontiers in cellular neuroscience · 2015Article
- Properties of submucosal venules in the rat distal colon.British journal of pharmacology · 2013Article
- Intraepithelial lymphocytes, goblet cells and VIP-IR submucosal neurons of jejunum rats infected with Toxoplasma gondii.International journal of experimental pathology · 2012Article
- Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system.Pharmacology & therapeutics · 2011Review
- Multifunctional rapidly adapting mechanosensitive enteric neurons (RAMEN) in the myenteric plexus of the guinea pig ileum.The Journal of physiology · 2009Article
- Alterations to enteric neural signaling underlie secretory abnormalities of the ileum in experimental colitis in the guinea pig.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Purinergic receptors and gastrointestinal secretomotor function.Purinergic signalling · 2008Article
- Autonomic nervous system and secretion across the intestinal mucosal surface.Autonomic neuroscience : basic & clinical · 2007Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Using a Ussing chamber and neuronal retrograde tracing with 1,1'-didodecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI) we characterized the afferent and efferent neuronal pathways which mediated distension-evoked secretion in the guinea-pig distal colon. 2. Acute capsaicin application (10 microM) to the serosal site of the Ussing chamber evoked a secretory response which was blocked by tetrodotoxin (1 microM), the combined application of the NK1 and NK3 receptor antagonists CP-99,994-1 and SR 142801 (1 microM), and by combined application of atropine (10 microM) and the VIP receptor antagonist VIP(6-28) (10 microM). Functional desensitization of extrinsic primary afferents by long-term application of capsaicin significantly diminished distension-evoked secretion by 46 %. 3. After functional desensitization by capsaicin, serosal application of gadolinium (100 microM) inhibited the distension-evoked chloride secretion by 54 %; the L-type Ca(2+) channel blocker nifedipine (1 microM) and the 5-HT(1P) receptor antagonist renzapride (1 microM) had no effect. The combination of atropine and VIP(6-28) or the combination of NK1 and NK3 receptor antagonists almost abolished distension-evoked secretion. 4. The secretory response evoked by electrical field stimulation, carbachol (1 microM) or VIP (1 microM) was not attenuated by gadolinium. Field stimulation-evoked chloride secretion was not affected by blockade of NK1 and NK3 receptors. 5. Twelve per cent of DiI-labelled submucosal neurones with projections to the mucosa were immunoreactive for choline acetyltransferase, substance P and calbindin and very probably represented intrinsic primary afferent neurones. 6. Distension-evoked chloride secretion was mediated by capsaicin-sensitive extrinsic primary afferents and by stretch-sensitive intrinsic primary afferent neurones. Both the extrinsic and intrinsic afferents converge on common efferent pathways. These pathways consist of VIPergic and cholinergic secretomotor neurones that are activated via NK1 and NK3 receptors.
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