ReviewThe Journal of physiology2001
Role of phosphate and calcium stores in muscle fatigue.
Review in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
99 citing papers in PubMed, 297 citations in OpenAlex.
- Effects of Resistance Training in Hypobaric vs. Normobaric Hypoxia on Circulating Ions and Hormones.International journal of environmental research and public health · 2022Trial
- Immediate effect of patellar kinesiology tape application on quadriceps peak moment following muscle fatigue: A randomized controlled study.Journal of musculoskeletal & neuronal interactions · 2020Trial
- Impact of stimulation frequency on neuromuscular fatigue.European journal of applied physiology · 2019Trial
- Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man.The Journal of physiology · 2002Trial
- Delaying task failure in high-intensity exercise: a Pi-afferent-effort framework for targeted sports nutrition.Journal of the International Society of Sports Nutrition · 2026Review
- Interplay between store-operated calcium entry and mitochondrial phosphate handling modulates force and fatigue during exercise.The Journal of physiology · 2026Article
- Impact of total creatine and accessible phosphate pool on endurance exercise: implications for muscle fibers bioenergetic specificity and creatine supplementation.European journal of applied physiology · 2026Article
- Mechanisms underlying age-related changes in the human skeletal muscle bioenergetic system.European journal of applied physiology · 2026Article
- Assessing the Recovery of Muscle Fatigue Using Shear Wave Elastography.Sports medicine - open · 2026Article
- An all-out sprint does not challenge the main goal of an endurance-based training session in cycling.European journal of applied physiology · 2026Article
- The effect of AMP deamination on skeletal muscle is stronger and more beneficial in extremely intense exercises to exhaustion and/or extremely stressing conditions.European journal of applied physiology · 2026Article
- Skeletal Muscle Fatigue in Rats Is More Consistently Related to Increased Inorganic Phosphate Concentration Than Acidosis.Acta physiologica (Oxford, England) · 2025Article
- Competing effects of activation history on force and cytosolic CaPflugers Archiv : European journal of physiology · 2025Article
- Biochemical origin of (near-) linear curvature constant (W')-European journal of applied physiology · 2025Article
- A Muscle Physiology-Based Framework for Quantifying Training Load in Resistance Exercises.Sports (Basel, Switzerland) · 2025Article
- Elastic textile-based wearable modulation of musculoskeletal load: A comprehensive review of passive exosuits and resistance clothing.Wearable technologies · 2025Review
- Involvement of Phosphate and the Consequences of Its High Consumption in Energy Metabolism and Muscle Functions.Journal of nutrition and metabolism · 2025Review
- PEuropean journal of applied physiology · 2025Article
- Alcohol ink-modified microfluidic paper-based analytical devices for enhanced white detection in simultaneous determination of multiple water quality indicators.Mikrochimica acta · 2024Article
- A novel kinetic model to demonstrate the independent effects of ATP and ADP/Pi concentrations on sarcomere function.PLoS computational biology · 2024Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intensive activity of muscles causes a decline in performance, known as fatigue, that is thought to be caused by the effects of metabolic changes on either the contractile machinery or the activation processes. The concentration of inorganic phosphate (P(i)) in the myoplasm ([P(i)](myo)) increases substantially during fatigue and affects both the myofibrillar proteins and the activation processes. It is known that a failure of sarcoplasmic reticulum (SR) Ca(2+) release contributes to fatigue and in this review we consider how raised [P(i)](myo) contributes to this process. Initial evidence came from the observation that increasing [P(i)](myo) causes reduced SR Ca(2+) release in both skinned and intact fibres. In fatigued muscles the store of releasable Ca(2+) in the SR declines mirroring the decline in SR Ca(2+) release. In muscle fibres with inoperative creatine kinase the rise of [P(i)](myo) is absent during fatigue and the failure of SR Ca(2+) release is delayed. These results can all be explained if inorganic phosphate can move from the myoplasm into the SR during fatigue and cause precipitation of CaP(i) within the SR. The relevance of this mechanism in different types of fatigue in humans is considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.