ArticleGenome research2001
Pattern and timing of gene duplication in animal genomes.
Article in Genome research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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Who cites it
51 citing papers in PubMed, 205 citations in OpenAlex.
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- Genome-Wide Identification and Analysis of theInternational journal of molecular sciences · 2022Article
- Diversification and Functional Evolution of HOX Proteins.Frontiers in cell and developmental biology · 2022Review
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- Deeply conserved synteny resolves early events in vertebrate evolution.Nature ecology & evolution · 2020Article
- Genome-wide comparative analysis of the BAHD superfamily in seven Rosaceae species and expression analysis in pear (Pyrus bretschneideri).BMC plant biology · 2020Article
- Purifying selection acts on coding and non-coding sequences of paralogous genes in Arabidopsis thaliana.BMC genomics · 2016Article
- Drosophotoxicology: An Emerging Research Area for Assessing Nanoparticles Interaction with Living Organisms.International journal of molecular sciences · 2016Review
- Comparative mapping for bighead carp (Aristichthys nobilis) against model and non-model fishes provides insights into the genomic evolution of cyprinids.Molecular genetics and genomics : MGG · 2015Article
- FlyNet: a versatile network prioritization server for the Drosophila community.Nucleic acids research · 2015Article
- Article
- Evolution of glucose utilization: glucokinase and glucokinase regulator protein.Molecular phylogenetics and evolution · 2014Review
- DrML: probabilistic modeling of gene duplications.Journal of computational biology : a journal of computational molecular cell biology · 2014Article
- The Molecular Evolutionary Patterns of the Insulin/FOXO Signaling Pathway.Evolutionary bioinformatics online · 2013Article
- Decoding plant and animal genome plasticity from differential paleo-evolutionary patterns and processes.Genome biology and evolution · 2012Article
- A genetic linkage map and comparative genome analysis of common carp (Cyprinus carpio L.) using microsatellites and SNPs.Molecular genetics and genomics : MGG · 2011Article
- Genome Size and Species Diversification.Evolutionary biology · 2010Article
- Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development.BMC developmental biology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Duplication of genes, giving rise to multigene families, has been a characteristic feature of the evolution of eukaryotic genomes. In the case of vertebrates, it has been proposed that an increase in gene number resulted from two rounds of duplication of the entire genome by polyploidization (the 2R hypothesis). In the most extensive test to date of this hypothesis, we compared gene numbers in homologous families and conducted phylogenetic analyses of gene families with two to eight members in the complete genomes of Caenorhabditis elegans and Drosophila melanogaster and the available portion of the human genome. Although the human genome showed a higher proportion of recent gene duplications than the other animal genomes, the proportion of duplications after the deuterostome-protostome split was constant across families, with no peak of such duplications in four-member families, contrary to the expectation of the 2R hypothesis. A substantial majority (70.9%) of human four-member families and four-member clusters in larger families showed topologies inconsistent with two rounds of polyploidization in vertebrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.