ArticleGenome research2001
Random monoallelic expression of three genes clustered within 60 kb of mouse t complex genomic DNA.
Article in Genome research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- X-Chromosome Inactivation and Autosomal Random Monoallelic Expression as "Faux Amis".Frontiers in cell and developmental biology · 2021Review
- Random monoallelic expression of autosomal genes: stochastic transcription and allele-level regulation.Nature reviews. Genetics · 2015Review
- Multi-scale approach for simulating time-delay biochemical reaction systems.IET systems biology · 2015Article
- Monoallelic expression of Krt12 gene during corneal-type epithelium differentiation of limbal stem cells.Investigative ophthalmology & visual science · 2010Article
- The application of restriction landmark genome scanning method for surveillance of non-mendelian inheritance in f(1) hybrids.Comparative and functional genomics · 2009Article
- Monoallelic expression of multiple genes in the CNS.PloS one · 2007Article
- RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer.Oncogene · 2007Article
- The cld mutation: narrowing the critical chromosomal region and selecting candidate genes.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Monoallelic expression of the protease inhibitor gene in humans, sheep, and cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- High concentrations of long interspersed nuclear element sequence distinguish monoallelically expressed genes.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
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7 authors.
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Abstract
Mammals achieve gene dosage control by (1) random X-chromosome inactivation in females, (2) parental origin-specific imprinting of selected autosomal genes, and (3) random autosomal inactivation. Genes belonging to the third category of epigenetic phenomenon are just now emerging, with only six identified so far. Here we report three additional genes, Nubp2, Igfals, and Jsap1, that show 50%-methylated CpG sites by Southern blot analyses and primarily monoallelic expression in single-cell allele-specific RT-PCR analysis of bone marrow stromal cells and hepatocytes. Furthermore, we show that, in contrast to X inactivation, alleles can switch between active and inactive states during the formation of daughter cells. These three genes are the first in their category to exist as a tight cluster, in the proximal region of mouse chromosome 17, providing a thus far unique example of a region of autosomal random monoallelic expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.