ArticleBMJ (Clinical research ed.)2001
Antibacterial prescribing and antibacterial resistance in English general practice: cross sectional study.
Article in BMJ (Clinical research ed.), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Interventions to improve antibiotic prescribing practices in ambulatory care.The Cochrane database of systematic reviews · 2005Pooled it
- A multifaceted intervention to reduce antibiotic prescribing among CHIldren with acute COugh and respiratory tract infection: the CHICO cluster RCT.Health technology assessment (Winchester, England) · 2023Trial
- Multi-faceted intervention to improve management of antibiotics for children presenting to primary care with acute cough and respiratory tract infection (CHICO): efficient cluster randomised controlled trial.BMJ (Clinical research ed.) · 2023Trial
- Antibiotic prescribing intensity and community UTI resistance: a cross-sectional ecological study.BJGP open · 2025Article
- E. coli bacteraemia and antimicrobial resistance following antimicrobial prescribing for urinary tract infection in the community.BMC infectious diseases · 2022Article
- Interventions for prudent antibiotic use in primary healthcare: an econometric analysis.BMC health services research · 2020Observational
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- Article
- Tobacco Smoking as a Risk Factor for Increased Antibiotic Prescription.American journal of preventive medicine · 2016Article
- Clinical predictors of antibiotic prescribing for acutely ill children in primary care: an observational study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2015Observational
- Acute otitis media in children-current treatment and prevention.Current infectious disease reports · 2015Article
- The TARGET cohort study protocol: a prospective primary care cohort study to derive and validate a clinical prediction rule to improve the targeting of antibiotics in children with respiratory tract illnesses.BMC health services research · 2013Observational
- Streptococcus pneumoniae non-susceptibility and outpatient antimicrobial prescribing rates at the Alaska Native Medical Center.International journal of circumpolar health · 2013Article
- Relative impact of clinical evidence and over-the-counter prescribing on topical antibiotic use for acute infective conjunctivitis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2009Article
- Curbing the menace of antimicrobial resistance in developing countries.Harm reduction journal · 2009Article
- Antibiotic prescribing patterns and hospital admissions with respiratory and urinary tract infections.European journal of clinical pharmacology · 2008Article
- Containing antibiotic resistance: decreased antibiotic-resistant coliform urinary tract infections with reduction in antibiotic prescribing by general practices.The British journal of general practice : the journal of the Royal College of General Practitioners · 2007Article
- Effect of antibiotic prescribing on antibiotic resistance in individual children in primary care: prospective cohort study.BMJ (Clinical research ed.) · 2007Article
- The state of play in the battle against antimicrobial resistance: a general practitioner perspective.The Journal of antimicrobial chemotherapy · 2007Article
- Multicentre study of antimicrobial resistance and antibiotic consumption among 6,780 patients with bloodstream infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2006Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo quantify the relation between community based antibacterial prescribing and antibacterial resistance in community acquired disease.
designCross sectional study of antibacterial prescribing and antibacterial resistance of routine isolates within individual practices and primary care groups.
setting405 general practices (38 groups) in south west and north west England.
main outcome measuresCorrelation between antibacterial prescribing and resistance for urinary coliforms and Streptococcus pneumoniae.
resultsAntibacterial resistance in urinary coliform isolates is common but the correlation with prescribing rates was relatively low for individual practices (ampicillin and amoxicillin r(s)=0.20, P=0.001; trimethoprim r(s)=0.24, P=0.0001) and primary care groups (ampicillin and amoxicillin r(s)=0.44, P=0.05; trimethoprim r(s)=0.31, P=0.09). Regression coefficients were also low; a practice prescribing 20% less ampicillin and amoxicillin than average would have about 1% fewer resistant isolates (0.94/100; 95% confidence interval 0.02 to 1.85). Resistance of S pneumoniae to both penicillin and erythromycin remains uncommon, and no clear relation with prescribing was found.
conclusionsRoutine microbiological isolates should not be used for surveillance of antibacterial resistance in the community or for monitoring the outcome of any change in antibacterial prescribing by general practitioners. Trying to reduce the overall level of antibiotic prescribing in UK general practice may not be the most effective strategy for reducing resistance in the community.
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