ArticleMolecular and cellular biology2001
Cdc25B functions as a novel coactivator for the steroid receptors.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 60 citations in OpenAlex.
- Comprehensive Analysis and Experimental Validation of a Novel Estrogen/Progesterone-Related Prognostic Signature for Endometrial Cancer.Journal of personalized medicine · 2022Article
- Neurogenic decisions require a cell cycle independent function of the CDC25B phosphatase.eLife · 2018Article
- Regulation of steroid hormone receptors and coregulators during the cell cycle highlights potential novel function in addition to roles as transcription factors.Nuclear receptor signaling · 2016Review
- Article
- Kizuna is a novel mitotic substrate for CDC25B phosphatase.Cell cycle (Georgetown, Tex.) · 2014Article
- Androgens upregulate Cdc25C protein by inhibiting its proteasomal and lysosomal degradation pathways.PloS one · 2013Article
- Identification of estrogen responsive genes using esophageal squamous cell carcinoma (ESCC) as a model.BMC systems biology · 2012Article
- The AR dependent cell cycle: mechanisms and cancer relevance.Molecular and cellular endocrinology · 2012Review
- Is Cdc25 a druggable target?Anti-cancer agents in medicinal chemistry · 2008Review
- AR, the cell cycle, and prostate cancer.Nuclear receptor signaling · 2008Review
- DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118.Oncogene · 2007Article
- Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development.Molecular and cellular biology · 2006Article
- The proliferating cell nuclear antigen regulates retinoic acid receptor transcriptional activity through direct protein-protein interaction.Nucleic acids research · 2005Article
- Article
- Dual-specificity phosphatases as targets for antineoplastic agents.Nature reviews. Drug discovery · 2002Review
- The roles of sex steroid receptor coregulators in cancer.Molecular cancer · 2002Review
- Progesterone receptors - animal models and cell signaling in breast cancer: Role of steroid receptor coactivators and corepressors of progesterone receptors in breast cancer.Breast cancer research : BCR · 2002Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously demonstrated that overexpression of Cdc25B in transgenic mice resulted in mammary gland hyperplasia and increased steroid hormone responsiveness. To address how Cdc25B enhances the hormone responsiveness in mammary glands, we showed that Cdc25B stimulates steroid receptor-dependent transcription in transient transfection assays and in a cell-free assay with chromatin templates. Surprisingly, the effect of Cdc25B on steroid receptors is independent of its protein phosphatase activity in vitro. The direct interactions of Cdc25B with steroid receptors, on the other hand, were evidenced in in vivo and in vitro assays, suggesting the potential direct contribution of Cdc25B on the steroid receptor-mediated transcription. In addition, p300/CBP-associated factor and CREB binding protein were shown to interact and synergize with Cdc25B and further enhance its coactivation activity. Thus, we have uncovered a novel function of Cdc25B that serves as a steroid receptor coactivator in addition to its role as a regulator for cell cycle progression. This dual function might likely contribute to its oncogenic action in breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.