Evidence map›Paper›PMID 11689674›Full record

ArticleJournal of virology2001

Transduction of cellular sequence by a human immunodeficiency virus type 1-derived vector.

G Sun, P K O'Neil, H Yu, Y Ron, B D Preston, J P Dougherty

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

G SunDepartment of Molecular Genetics & Microbiology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.
P K O'Neil
H Yu
Y Ron
B D Preston
J P Dougherty
Johnson University · USYale University · USHoward Hughes Medical Institute · US

Funding

GENE THERAPY FOR EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITR01NS038272 · NINDS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI RON, YACOV · 1999 to 2007
$1.7M
DETERMINATION OF RETROVIRUS MUTATION RATESR01CA050777 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI DOUGHERTY, JOSEPH · 1995 to 2003
$1.0M
HIV FRAMESHIFTING--FROM BIOLOGY TO THERAPEUTICSR01AI043886 · NIAID · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI PELTZ, STUART W · 1999 to 2003
$996k
BIOCHEMICAL DETERMINANTS OF RETROVIRAL MUTATIONR01AI034834 · NIAID · UNIVERSITY OF WASHINGTON · PI PRESTON, BRADLEY D · 1994 to 2002
$876k
BIOCHEMICAL DETERMINANTS OF RETROVIRAL MUTATIONR21AI034834 · NIAID · UNIVERSITY OF UTAH · PI PRESTON, BRADLEY D · 1998 to 1998
–
HIV FRAMESHIFTING--FROM BIOLOGY TO THERAPEUTICSR21AI043886 · NIAID · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI PELTZ, STUART W · 1999 to 1999
–
DETERMINATION OF RETROVIRUS MUTATION RATESR29CA050777 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI DOUGHERTY, JOSEPH · 1989 to 1993
–
NCI NIH HHS CA50777NIAID NIH HHS AI34834NIAID NIH HHS AI43886NINDS NIH HHS NS38272NINDS NIH HHS R01 NS038272
6 · The paper itself

Abstract

During studies examining the rate of human immunodeficiency virus type 1 (HIV-1) mutation in a single cycle of replication, the 5' long terminal repeat of one progeny provirus was found to contain an insertion of 147 bp including an entire tRNA sequence as well as an additional 66 bp insertion of nonviral origin. Database searches revealed that 65 of 66 bp aligned with the human CpG island sequence found on chromosomes 6, 14, and 17. Therefore it seems probable that it is of human cellular sequence origin and was transduced by HIV-1. This is the first demonstration that HIV-1 can capture a cellular sequence. The site of integration of the parental provirus was mapped to chromosome 1p32.1. Sequence with homology to the transduced CpG island was not found on chromosome 1, suggesting that the transduced cellular sequence was not linked to the site of viral integration.

Indexed as

Genetic VectorsBase SequenceCpG IslandsDNA, ViralHIV-1HumansMolecular Sequence DataPolymerase Chain ReactionTransduction, GeneticVirus IntegrationVirus ReplicationDNA, Viral

Identifiers

PMID11689674
PMCPMC114779
OpenAlexW2166359723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.