Evidence map›Paper›PMID 11689671›Full record

ArticleJournal of virology2001

Interleukin-4 up-regulates mouse mammary tumor virus expression yet is not required for in vivo virus spread.

J Czarneski, J Meyers, T Peng, V Abraham, R Mick, S R Ross

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

J CzarneskiDepartment of Microbiology, Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6142, USA.
J Meyers
T Peng
V Abraham
R Mick
S R Ross
University of Pennsylvania · US

Funding

GENETICS OF SUSCEPTIBILTY TO MMTV INDUCED MAMMARY TUMORSR01CA045954 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ROSS, SUSAN R · 1987 to 2006
$2.0M
LYMPHOCYTE HOMING AND ADHESION IN MMTV TUMORIGENESISF32CA083344 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CZARNESKI, JENNIFER E · 1999 to 2002
$90k
NCI NIH HHS F32 CA083344NCI NIH HHS F32 CA83344NCI NIH HHS R01 CA045954NCI NIH HHS R01-CA45954
6 · The paper itself

Abstract

The mouse mammary tumor virus (MMTV) superantigen induces T-cell production of cytokines, such as interleukin-4, which in turn increase MMTV transcription. However, interleukin-4 is not required for in vivo virus spread, because mice lacking interleukin-4 or the STAT6 transcription factor showed wild-type infection of lymphoid and mammary tissue. In spite of this, mammary tumor incidence was decreased in STAT6 null mice.

Indexed as

AnimalsInterleukin-4Mammary Tumor Virus, MouseMiceMice, Inbred StrainsMice, KnockoutSignal TransductionSTAT6 Transcription FactorTrans-ActivatorsUp-RegulationInterleukin-4Stat6 protein, mouseSTAT6 Transcription FactorTrans-Activators

Identifiers

PMID11689671
PMCPMC114776
OpenAlexW2117508455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.