ArticleJournal of virology2001
Expression of endogenous betaretroviruses in the ovine uterus: effects of neonatal age, estrous cycle, pregnancy, and progesterone.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 84 citations in OpenAlex.
- Novel Aspects of the Physiology of Pregnancy in Domestic Ruminants.Animals : an open access journal from MDPI · 2025Review
- Exogenous Jaagsiekte sheep retrovirus (JSRV) Inner Mongolia strain: whole-genome characterization and viral particle packaging.Frontiers in veterinary science · 2025Article
- Construction of a molecular clone of ovine enzootic nasal tumor virus.Virology journal · 2016Article
- Retroviral envelope gene captures and syncytin exaptation for placentation in marsupials.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- "Ménage à Trois": the evolutionary interplay between JSRV, enJSRVs and domestic sheep.Viruses · 2014Review
- Endogenous retroviruses in domestic animals.Current genomics · 2014Article
- Host species barriers to Jaagsiekte sheep retrovirus replication and carcinogenesis.Journal of virology · 2013Article
- Captured retroviral envelope syncytin gene associated with the unique placental structure of higher ruminants.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Application of next generation sequencing in mammalian embryogenomics: lessons learned from endogenous betaretroviruses of sheep.Animal reproduction science · 2012Review
- Expression of endogenous beta retroviruses and Hyal-2 mRNA in immune organs of fetuses and lambs.Virologica Sinica · 2012Article
- No biological evidence of XMRV infection in cervical smears from HIV/ HPV positive and negative Kenyan women.PloS one · 2012Article
- Identification of novel endogenous betaretroviruses which are transcribed in the bovine placenta.Journal of virology · 2011Article
- Endogenous retroviruses in trophoblast differentiation and placental development.American journal of reproductive immunology (New York, N.Y. : 1989) · 2010Review
- Viral particles of endogenous betaretroviruses are released in the sheep uterus and infect the conceptus trophectoderm in a transspecies embryo transfer model.Journal of virology · 2010Article
- Article
- Interplay between ovine bone marrow stromal cell antigen 2/tetherin and endogenous retroviruses.Journal of virology · 2010Article
- Novel pathways for implantation and establishment and maintenance of pregnancy in mammals.Molecular human reproduction · 2010Review
- Friendly viruses: the special relationship between endogenous retroviruses and their host.Annals of the New York Academy of Sciences · 2009Article
- A paradigm for virus-host coevolution: sequential counter-adaptations between endogenous and exogenous retroviruses.PLoS pathogens · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The ovine genome contains 15 to 20 copies of endogenous retroviruses (enJSRVs) highly related to the oncogenic jaagsiekte sheep retrovirus (JSRV) and enzootic nasal tumor virus. enJSRVs are highly expressed in the endometrial lumenal epithelia (LE) and glandular epithelia (GE) of the ovine uterus. The effects of neonatal age, estrous cycle, pregnancy, and progesterone on expression of enJSRVs in the ovine uterus were determined. Expression of enJSRV RNAs was absent from the uterus of ewes at birth, but enJSRV RNAs were expressed specifically in the LE and developing GE from postnatal day (PND) 7 to PND 56. In adult ewes, enJSRV RNAs were detected only in the epithelia of the uterine endometrium, as well as epithelia of the oviduct, cervix, and vagina. In cyclic ewes, endometrial enJSRV RNA abundance was lowest on day 1, increased 12-fold between days 1 and 13, and then decreased to day 15. In pregnant ewes, levels of endometrial enJSRV RNAs were high on day 11, increased to day 13, and then decreased to day 19. In day 17 and 19 conceptuses, enJSRV RNAs were also detected in binucleate cells of the trophectoderm. Immunoreactive JSRV capsid and envelope proteins were detected in the endometrial LE and GE, as well as in the binucleate cells of the conceptus. In transfection assays utilizing ovine endometrial LE cells, progesterone increased transcriptional activity of several enJSRV long terminal repeats. Collectively, these results indicate that transcription of enJSRVs in the endometrial epithelia of the ovine uterus is increased by progesterone and might support a role for enJSRVs in conceptus-endometrium interactions during the peri-implantation period and early placental morphogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.