ArticleJournal of virology2001
Effects of limiting homology at the site of intermolecular recombinogenic template switching during Moloney murine leukemia virus replication.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Aberrant strand transfer events across multiple stages of reverse transcription shape the heterogeneous landscape of the HIV-1 reservoir.Communications biology · 2025Article
- Template-switching artifacts resemble alternative polyadenylation.BMC genomics · 2019Article
- Analysis of HIV-1 intersubtype recombination breakpoints suggests region with high pairing probability may be a more fundamental factor than sequence similarity affecting HIV-1 recombination.Virology journal · 2016Article
- Resolution of Specific Nucleotide Mismatches by Wild-Type and AZT-Resistant Reverse Transcriptases during HIV-1 Replication.Journal of molecular biology · 2016Article
- Complex recombination patterns arising during geminivirus coinfections preserve and demarcate biologically important intra-genome interaction networks.PLoS pathogens · 2011Article
- Article
- Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success.Virology journal · 2009Article
- The remarkable frequency of human immunodeficiency virus type 1 genetic recombination.Microbiology and molecular biology reviews : MMBR · 2009Review
- Influence of vector design and host cell on the mechanism of recombination and emergence of mutant subpopulations of replicating retroviral vectors.BMC molecular biology · 2009Article
- Pseudodiploid genome organization AIDS full-length human immunodeficiency virus type 1 DNA synthesis.Journal of virology · 2008Article
- Effects of identity minimization on Moloney murine leukemia virus template recognition and frequent tertiary template-directed insertions during nonhomologous recombination.Journal of virology · 2007Article
- Hairpin-induced tRNA-mediated (HITME) recombination in HIV-1.Nucleic acids research · 2006Article
- Precise identification of endogenous proviruses of NFS/N mice participating in recombination with moloney ecotropic murine leukemia virus (MuLV) to generate polytropic MuLVs.Journal of virology · 2005Article
- An RNA secondary structure bias for non-homologous reverse transcriptase-mediated deletions in vivo.Nucleic acids research · 2004Article
- Mismatch extension during strong stop strand transfer and minimal homology requirements for replicative template switching during Moloney murine leukemia virus replication.Journal of molecular biology · 2003Article
- Human immunodeficiency virus type 1 genetic recombination is more frequent than that of Moloney murine leukemia virus despite similar template switching rates.Journal of virology · 2003Article
- Dimerization and template switching in the 5' untranslated region between various subtypes of human immunodeficiency virus type 1.Journal of virology · 2003Article
- Base pairing among three cis-acting sequences contributes to template switching during hepadnavirus reverse transcription.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Editing site recognition and nucleotide insertion are separable processes in Physarum mitochondria.The EMBO journal · 2002Article
- In vivo RNA-directed transcription, with template switching, by a mammalian RNA polymerase.The EMBO journal · 2002Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A Moloney murine leukemia virus-based single-replication-cycle assay was developed to study the effects of limiting the extent of template and primer strand complementarity on recombinogenic template switching. This system mimicked forced copy choice recombination in which nascent DNA transfers from the end of a donor template to an acceptor position on the other copackaged RNA. When acceptor target regions with different extents of complementarity to the transferring DNA were tested, efficient recombination occurred with as few as 14 complementary nucleotides. The frequencies of correct targeting, transfer-associated errors, mismatch extension, and transfer before reaching the end of the donor template were determined. All four molecular events occurred, with their proportions varying depending on the nature of acceptor/transferring DNA complementarity. When complementarity was severely limited, recombination was inefficient and most products resulted from aberrant second-strand transfer rather than from forced template switching between RNAs. Other classes of reverse transcription products, including some that resulted from template switching between virus and host sequences, were also observed when homology between the acceptor and donor was limited.
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