ArticleThe EMBO journal2001
A role for coactivators and histone acetylation in estrogen receptor alpha-mediated transcription initiation.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 101 citations in OpenAlex.
- The HIV Reservoir and Immune Landscape Across the Life Course of Women: Implications for Cure Strategies.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- Single-cell transcriptional atlas of human breast cancers and model systems.Clinical and translational medicine · 2024Article
- DNA methylation and demethylation shape sexual differentiation of neurochemical phenotype.Hormones and behavior · 2023Article
- Bioinformatics analysis reveals the potential target of rosiglitazone as an antiangiogenic agent for breast cancer therapy.BMC genomic data · 2022Article
- Oncohistone Mutations Occur at Functional Sites of Regulatory ADP-Ribosylation.Cancer research · 2022Article
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- HBI-8000, HUYABIO Lead Clinical Program, Is a Selective Histone Deacetylase Inhibitor With Therapeutic Benefits in Leukemia and in Solid Tumors.Frontiers in oncology · 2021Review
- Genetic and epigenetic sex-specific adaptations to endurance exercise.Epigenetics · 2019Review
- Dynamic assembly and activation of estrogen receptor α enhancers through coregulator switching.Genes & development · 2017Article
- Identification of MYST3 as a novel epigenetic activator of ERα frequently amplified in breast cancer.Oncogene · 2017Article
- Environmental influences on the female epigenome and behavior.Environmental epigenetics · 2016Article
- Epigenetics and sex differences in the brain: A genome-wide comparison of histone-3 lysine-4 trimethylation (H3K4me3) in male and female mice.Experimental neurology · 2015Review
- Inhibition of BET proteins impairs estrogen-mediated growth and transcription in breast cancers by pausing RNA polymerase advancement.Breast cancer research and treatment · 2015Article
- H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription.Oncotarget · 2015Article
- Up-regulation of type II collagen gene by 17β-estradiol in articular chondrocytes involves Sp1/3, Sox-9, and estrogen receptor α.Journal of molecular medicine (Berlin, Germany) · 2014Article
- Epigenetic regulation of estrogen-dependent memory.Frontiers in neuroendocrinology · 2014Review
- Transient estrogen receptor binding and p300 redistribution support a squelching mechanism for estradiol-repressed genes.Molecular endocrinology (Baltimore, Md.) · 2014Article
- An H2A histone isotype regulates estrogen receptor target genes by mediating enhancer-promoter-3'-UTR interactions in breast cancer cells.Nucleic acids research · 2014Article
- Epigenetic contributions to hormonally-mediated sexual differentiation of the brain.Journal of neuroendocrinology · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Transcriptional regulation by estrogen receptor alpha (ERalpha) involves protein-protein interactions among the receptor, its associated coactivators and the RNA polymerase II transcriptional machinery. We have used an in vitro chromatin assembly and transcription system to examine the biochemistry of interactions among ERalpha, the SRC proteins and p300/CBP. Using polypeptides designed to block specific receptor- cofactor or cofactor-cofactor interactions, we show that interactions among ERalpha, its coactivators and the RNA pol II machinery are all required for ERalpha- mediated transcription. Furthermore, we show that ERalpha-SRC-p300/CBP interactions are necessary and sufficient for the targeted acetylation of nucleosomal histones on estrogen-responsive promoters in the absence of transcription. The protein-protein interactions required for histone acetylation constitute a subset of the interactions required for transcriptional activation. Finally, we show that the major role of SRC-p300/CBP interactions is to enhance ERalpha- mediated transcription initiation, and they have little or no role in stimulating subsequent rounds of transcription. Together, our results indicate a specific role for the SRC and p300/CBP coactivators, as well as targeted histone acetylation, in ERalpha-mediated transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.