ArticleThe EMBO journal2001
Two mechanisms activate PTPalpha during mitosis.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Glucose-mediated N-glycosylation of RPTPα affects its subcellular localization and Src activation.Oncogene · 2023Article
- The tyrosine kinase v-Src causes mitotic slippage by phosphorylating an inhibitory tyrosine residue of Cdk1.The Journal of biological chemistry · 2018Article
- Cytokinesis Failure Leading to Chromosome Instability in v-Src-Induced Oncogenesis.International journal of molecular sciences · 2017Review
- Protective role for lipid modifications of Src-family kinases against chromosome missegregation.Scientific reports · 2016Article
- Cell Transformation by PTP1B Truncated Mutants Found in Human Colon and Thyroid Tumors.PloS one · 2016Article
- Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts.The Journal of biological chemistry · 2014Article
- Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex.Molecular and cellular biology · 2014Article
- Receptor protein-tyrosine phosphatase α regulates focal adhesion kinase phosphorylation and ErbB2 oncoprotein-mediated mammary epithelial cell motility.The Journal of biological chemistry · 2013Article
- c-Src but not Fyn promotes proper spindle orientation in early prometaphase.The Journal of biological chemistry · 2012Article
- Receptor-like protein-tyrosine phosphatase α enhances cell surface expression of neural adhesion molecule NB-3.The Journal of biological chemistry · 2011Article
- Activation of Src and transformation by an RPTPα splice mutant found in human tumours.The EMBO journal · 2011Article
- Serine dephosphorylation of receptor protein tyrosine phosphatase alpha in mitosis induces Src binding and activation.Molecular and cellular biology · 2010Article
- Extracellular domain dependence of PTPalpha transforming activity.Genes to cells : devoted to molecular & cellular mechanisms · 2010Article
- A site-specific, multiplexed kinase activity assay using stable-isotope dilution and high-resolution mass spectrometry.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells.The Journal of biological chemistry · 2008Article
- Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi.International journal of cancer · 2008Article
- Neu-mediated phosphorylation of protein tyrosine phosphatase epsilon is critical for activation of Src in mammary tumor cells.Oncogene · 2007Article
- Association of tyrosine phosphatase epsilon with microtubules inhibits phosphatase activity and is regulated by the epidermal growth factor receptor.Molecular and cellular biology · 2007Article
- Interdependence of cell attachment and cell cycle signaling.Current opinion in cell biology · 2006Review
- Receptor protein tyrosine phosphatase from stem cells to mature glial cells of the central nervous system.Journal of molecular neuroscience : MN · 2006Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We show that, dependent on serine hyperphosphorylation, protein tyrosine phosphatase alpha (PTPalpha) is activated by two different mechanisms during mitosis: its specific activity increases and its inhibitory binding to Grb2 decreases. The latter effect probably abates Grb2 inhibition of the phosphotyrosine displacement process that is required specifically for Src dephosphorylation and causes a mitotic increase in transient PTPalpha-Src binding. Thus, part of the increased protein tyrosine phosphatase activity may be specific for Src family members. These effects cease along with Src activation when cells exit mitosis. Src is not activated in mitosis in PTPalpha-knockout cells, indicating a unique mitotic role for this phosphatase. The activation of PTPalpha, combined with the effects of mitotic Cdc2-mediated phosphorylations of Src, quantitatively accounts for the mitotic activation of Src, indicating that PTPalpha is the membrane-bound, serine phosphorylation-activated, protein tyrosine phosphatase that activates Src during mitosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.