ArticleThe EMBO journal2001
Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 101 citations in OpenAlex.
- Overcoming the response plateau in multiple myeloma: a novel bortezomib-based strategy for secondary induction and high-yield CD34+ stem cell mobilization.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Trial
- Review
- Plasma Fibronectin Drives Macrophage Elongation via Integrin β3-Tie2 Axis in Blood Clots.Cancers · 2025Article
- Nature's Elixir for Cancer Treatment: Targeting Tumor-induced Neovascularization.Current medicinal chemistry · 2024Review
- Endothelial progenitor cells in the host defense response.Pharmacology & therapeutics · 2023Review
- Introduction to DOK2 and its potential role in cancer.Physiological research · 2021Review
- Roles of miR-640 and Zinc Finger Protein 91 (ZFP91) in Angiopoietin-1-Induced In Vitro Angiogenesis.Cells · 2020Article
- Polarization and sprouting of endothelial cells by angiopoietin-1 require PAK2 and paxillin-dependent Cdc42 activation.Molecular biology of the cell · 2019Article
- Region-Specific Dok2 Overexpression Associates with Poor Prognosis in Human Astrocytoma.Molecular neurobiology · 2018Article
- Review
- Pro-angiogenic Role of Insulin: From Physiology to Pathology.Frontiers in physiology · 2017Review
- Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII.eLife · 2016Article
- Requisite role for Nck adaptors in cardiovascular development, endothelial-to-mesenchymal transition, and directed cell migration.Molecular and cellular biology · 2015Article
- Tie2 and Eph receptor tyrosine kinase activation and signaling.Cold Spring Harbor perspectives in biology · 2014Review
- PAK signalling during the development and progression of cancer.Nature reviews. Cancer · 2014Review
- Potential compensation among group I PAK members in hindlimb ischemia and wound healing.PloS one · 2014Article
- Signaling Network Map of Endothelial TEK Tyrosine Kinase.Journal of signal transduction · 2014Article
- Regulation of angiopoietin-1/Tie-2 receptor signaling in endothelial cells by dual-specificity phosphatases 1, 4, and 5.Journal of the American Heart Association · 2013Article
- Plasma Fibronectin Promotes Tumor Cell Survival and Invasion through Regulation of Tie2.Journal of Cancer · 2013Article
- Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer.Molecular oncology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tek/Tie-2 is an endothelial cell (EC)-specific receptor tyrosine kinase that plays a critical role in angiogenesis via its regulation by the angiopoietin family of growth factor ligands. Angiopoietin-1 (Ang1) can promote EC migration; however, the signaling mechanisms underlying this process remain elusive. Here we demonstrate that Dok-R/Dok-2 can associate with Tek in ECs following Ang1 stimulation, resulting in tyrosine phosphorylation of Dok-R and the subsequent recruitment of Nck and the p21-activating kinase (Pak/Pak1) to the activated receptor. Ang1-mediated migration is increased upon Dok-R overexpression and this requires a functional Nck binding site on Dok-R. Localization of this Dok-R-Nck-Pak complex to the activated Tek receptor at the cellular membrane is coincident with activation of Pak kinase. The ability of Dok-R to bind Nck is required for maximal activation of Pak and overexpression of Pak results in increased Ang1-mediated cell motility. Our study outlines a novel signaling pathway underlying Ang1-driven cell migration that involves Dok-R and its recruitment of Nck and the subsequent activation of Pak.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.