Evidence map›Paper›PMID 11687709›Full record

ReviewScience's STKE : signal transduction knowledge environment2001

Signaling by fibroblast growth factors: the inside story.

M Goldfarb

Abstract readReview
In one paragraph

Review in Science's STKE : signal transduction knowledge environment, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 73 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

M GoldfarbDepartment of Biochemistry and Molecular Biology, Box 1020, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029, USA. Mitchell.Goldfarb@mssm.edu
Mount Sinai Hospital · US

Funding

NOVEL NEURONAL SIGNALING MODULER01NS039906 · NINDS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GOLDFARB, MITCHELL · 2000 to 2007
$2.7M
NINDS NIH HHS R01 NS039906
6 · The paper itself

Abstract

Polypeptide growth factors bind to the extracellular domains of cell surface receptors, triggering activation of receptor-intrinsic or receptor-associated protein kinases. Although this central thesis is widely accepted, one family of proteins, the fibroblast growth factors (FGFs), have for more than a decade attracted a research "counterculture" looking for direct FGF actions inside cells. Goldfarb discusses how the search for alternative signaling pathways is moving mainstream with the help of two recent publications reporting specific intracellular targets for FGF and FGF-like proteins.

Indexed as

AnimalsCell DifferentiationCell DivisionFibroblast Growth FactorsHumansLigandsMAP Kinase Signaling SystemReceptors, Fibroblast Growth FactorRNA Processing, Post-TranscriptionalSignal TransductionFibroblast Growth FactorsLigandsReceptors, Fibroblast Growth Factor

Identifiers

PMID11687709
PMCPMC3208904
OpenAlexW2098810297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.