ArticleClinical and diagnostic laboratory immunology2001
Inhibition of ganciclovir-susceptible and -resistant human cytomegalovirus clinical isolates by the benzimidazole L-riboside 1263W94.
Article in Clinical and diagnostic laboratory immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The effective multiplicity of infection for HCMV depends on the activity of the cellular 20S proteasome.Journal of virology · 2025Article
- Lamin post-translational modifications: emerging toggles of nuclear organization and function.Trends in biochemical sciences · 2021Review
- The Cytomegalovirus Protein Kinase pUL97:Host Interactions, Regulatory Mechanisms and Antiviral Drug Targeting.Microorganisms · 2020Review
- Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection.Italian journal of pediatrics · 2015Article
- An epistatic relationship between the viral protein kinase UL97 and the UL133-UL138 latency locus during the human cytomegalovirus lytic cycle.Journal of virology · 2014Article
- The ULb' region of the human cytomegalovirus genome confers an increased requirement for the viral protein kinase UL97.Journal of virology · 2013Article
- The search for new therapies for human cytomegalovirus infections.Virus research · 2011Review
- Maribavir inhibits epstein-barr virus transcription in addition to viral DNA replication.Journal of virology · 2009Article
- Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.Reviews in medical virology · 2009Review
- Conserved herpesvirus protein kinases.Biochimica et biophysica acta · 2008Review
- Preparation and ocular pharmacokinetics of ganciclovir liposomes.The AAPS journal · 2007Article
- Human cytomegalovirus UL27 is not required for viral replication in human tissue implanted in SCID mice.Virology journal · 2006Article
- In Vitro Anti-Cytomegalovirus Activity of Kampo (Japanese Herbal) Medicine.Evidence-based complementary and alternative medicine : eCAM · 2004Article
- Novel chemical class of pUL97 protein kinase-specific inhibitors with strong anticytomegaloviral activity.Antimicrobial agents and chemotherapy · 2004Article
- Activities of benzimidazole D- and L-ribonucleosides in animal models of cytomegalovirus infections.Antimicrobial agents and chemotherapy · 2004Article
- Phenotypic drug susceptibility assay for influenza virus neuraminidase inhibitors.Clinical and diagnostic laboratory immunology · 2004Article
- In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses.Antimicrobial agents and chemotherapy · 2003Article
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Authors and funding
6 authors.
Funding
Abstract
The average 50% inhibitory concentration (IC(50)) values for AD169 were 0.22 +/- 0.09 microM 1263W94 and 5.36 +/- 0.12 microM ganciclovir. For 35 human cytomegalovirus (HCMV) clinical isolates the average IC(50) was 0.42 +/- 0.09 microM 1263W94, and for 26 ganciclovir-susceptible HCMV clinical isolates the average IC(50) was 3.78 +/- 1.62 microM ganciclovir. Nine HCMV clinical isolates that were resistant to ganciclovir were completely susceptible to 1263W94.
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