ArticleClinical and diagnostic laboratory immunology2001
Modulation of Mycobacterium bovis-specific responses of bovine peripheral blood mononuclear cells by 1,25-dihydroxyvitamin D(3).
Article in Clinical and diagnostic laboratory immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Prevalence ofFrontiers in veterinary science · 2024Pooled it
- Dietary supplementation with 25-hydroxycholecalciferol is more effective than cholecalciferol in improving reproductive performance in aged duck breeders.Journal of animal science · 2026Article
- Bovine Immunity and Vitamin DMicroorganisms · 2022Review
- Effects of 1,25-Dihydroxyvitamin DFrontiers in veterinary science · 2022Article
- Johne's Disease in Dairy Cattle: An Immunogenetic Perspective.Frontiers in veterinary science · 2021Review
- Exogenous Vitamin DFrontiers in cellular and infection microbiology · 2021Article
- Vitamin D increases killing of intracellularParasitology · 2020Article
- Determinants of vitamin D status in Kenyan calves.Scientific reports · 2020Article
- Vitamin D Metabolism and Profiling in Veterinary Species.Metabolites · 2020Review
- 1,25(OH)D vitamin D promotes NOS2 expression in response to bacterial and viral PAMPs in primary bovine salivary gland fibroblasts.Veterinary research communications · 2020Article
- Relationship between expression pattern of vitamin D receptor, 1 alpha-hydroxylase enzyme, and chemokine RANTES genes and selected serum parameters during transition period in Holstein dairy cows.Veterinary record open · 2020Article
- Effects of a Change from an Indoor-Based Total Mixed Ration to a Rotational Pasture System Combined with a Moderate Concentrate Feed Supply on Immunological Cell and Blood Parameters of Dairy Cows.Veterinary sciences · 2019Article
- 1,25-Dihydroxyvitamin D3 modulates the phenotype and function of Monocyte derived dendritic cells in cattle.BMC veterinary research · 2017Article
- 1,25-Dihydroxyvitamin D3 modulates calcium transport in goat mammary epithelial cells in a dose- and energy-dependent manner.Journal of animal science and biotechnology · 2016Article
- Vitamin D status and TB treatment outcomes in adult patients in Tanzania: a cohort study.BMJ open · 2013Article
- Nitric oxide not apoptosis mediates differential killing of Mycobacterium bovis in bovine macrophages.PloS one · 2013Article
- Vitamin D signaling in the bovine immune system: a model for understanding human vitamin D requirements.Nutrients · 2012Review
- Regulation of Mycobacterium-specific mononuclear cell responses by 25-hydroxyvitamin D3.PloS one · 2011Article
- Reactivation of tuberculosis and vitamin D deficiency: the contribution of diet and exposure to sunlight.Thorax · 2007Article
- 1,25-dihydroxyvitamin D3 and development of tuberculosis in cattle.Clinical and diagnostic laboratory immunology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Historically, administration of vitamin D has been considered beneficial in the treatment of tuberculosis. The interaction of this vitamin [i.e., 1,25-dihdroxyvitamin D(3) [1,25(OH)(2)D(3)]] with the antitubercular immune response, however, is not clear. In the present study, in vitro recall responses of peripheral blood mononuclear cells (PBMC) from cattle infected with Mycobacterium bovis were used to study the immune-modulatory effects of 1,25(OH)(2)D(3) on M. bovis-specific responses in vitro. Addition of 1 or 10 nM 1,25(OH)(2)D(3) inhibited M. bovis-specific proliferative responses of PBMC from M. bovis-infected cattle, affecting predominantly the CD4(+) cell subset. In addition, 1,25(OH)(2)D(3) inhibited M. bovis-specific gamma interferon (IFN-gamma) production yet enhanced M. bovis-specific nitric oxide (NO) production. Lymphocyte apoptosis, measured by flow cytometry using annexin-V staining, was diminished by addition of 1,25(OH)(2)D(3) to PBMC cultures. These findings support the current hypothesis that 1,25(OH)(2)D(3) enhances mycobacterial killing by increasing NO production, a potent antimicrobial mechanism of activated macrophages, and suggest that 1,25(OH)(2)D(3) limits host damage by decreasing M. bovis-induced IFN-gamma production.
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Registered trials
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