SynthesisThe Cochrane database of systematic reviews2001
Directly observed therapy for treating tuberculosis.
Synthesis in The Cochrane database of systematic reviews, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02082340 (Innovative Approach in Tuberculosis Care in Armenia), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Innovative Approach in Tuberculosis Care in Armenia
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Directly observed therapy for treating tuberculosis.The Cochrane database of systematic reviews · 2015Pooled it
- Trial
- Factors Influencing Treatment Adherence Among Drug-Sensitive Tuberculosis (DS-TB) Patients in Armenia: A Qualitative Study.Patient preference and adherence · 2022Article
- In silico identification of novel chemical compounds with antituberculosis activity for the inhibition of InhA and EthR proteins from Mycobacterium tuberculosis.Journal of clinical tuberculosis and other mycobacterial diseases · 2021Article
- Celebrating methodological challenges and changes: reflecting on the emergence and importance of the role of qualitative evidence in Cochrane reviews.Systematic reviews · 2013Article
- Sarcoidosis following Mycobacterium tuberculosis infection: Coincidence or consequence.Respiratory medicine case reports · 2013Article
- Directly observed therapy reduces tuberculosis-specific mortality: a population-based follow-up study in Taipei, Taiwan.PloS one · 2013Article
- DOT associated with reduced all-cause mortality among tuberculosis patients in Taipei, Taiwan, 2006-2008.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2012Article
- Does directly observed therapy (DOT) reduce drug resistant tuberculosis?BMC public health · 2011Article
- The Use of Research Evidence in Two International Organizations' Recommendations about Health Systems.Healthcare policy = Politiques de sante · 2009Article
- Determinants of treatment adherence among smear-positive pulmonary tuberculosis patients in Southern Ethiopia.PLoS medicine · 2007Article
- Effect of a hospital-based case management approach on treatment outcome of patients with tuberculosis.Journal of the Formosan Medical Association = Taiwan yi zhi · 2006Article
- Modeling and simulation of adherence: approaches and applications in therapeutics.The AAPS journal · 2005Review
- DOTS improves treatment outcomes and service coverage for tuberculosis in South Ethiopia: a retrospective trend analysis.BMC public health · 2005Article
- Critical reflections on evidence, ethics and effectiveness in the management of tuberculosis: public health and global perspectives.BMC medical ethics · 2004Article
Corrections and comments
- Updated by
Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUp to half the people with tuberculosis do not complete their treatment. Strategies to improve adherence to diagnostic and treatment regimens are therefore important.
objectivesTo assess the effects of directly observed therapy by an appointed agent (health worker, community volunteer, or family member) on cure and treatment completion in people on treatment for tuberculosis. SEARCH STRATEGY: We searched The Cochrane Controlled Trials Register, the Cochrane Infectious Diseases Group specialized trials register, MEDLINE, EMBASE, LILACS, and reference lists of articles. We also contacted experts in the field. SELECTION CRITERIA: Randomized and quasi-randomized trials of direct observation of tablet swallowing compared with self treatment for tuberculosis. DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed trial quality and extracted data. MAIN
resultsFour studies (n = 1603 participants) included. There was no difference detected between direct observation and self treatment for cure (Relative Risk [RR] 1.06, 95% confidence interval [CI] 0.98 to 1.14); and for cure plus treatment completion (RR 1.06, 95% CI 1.00 to 1.13). A stratified analysis by the appointed agent (health professional, lay health worker, or family/community member) did not reveal any important differences. One study conducted in an optimal setting in which patients were given a choice of supervisor did show modest benefit: cure (RR 1.13, 95% CI 1.04 to 1.24); cure plus treatment completion (RR 1.11, 95% CI 1.03 to 1.18). REVIEWER'S
conclusionsRandomized trials provide no evidence that directly observed therapy in low and middle income country settings improves cure or treatment completion rates in patients with tuberculosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.