Evidence map›Paper›PMID 11687087›Full record

SynthesisThe Cochrane database of systematic reviews2001

Magnesium supplementation in pregnancy.

M Makrides, C A Crowther

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in The Cochrane database of systematic reviews, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 12 syntheses or guidelines pooled it.

  1. Guided imagery for treating hypertension in pregnancy.The Cochrane database of systematic reviews · 2019
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Magnesium supplementation in pregnancy.The Cochrane database of systematic reviews · 2014
    Pooled it
  6. Concordance of effects of medical interventions on hospital admission and readmission rates with effects on mortality.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2013
    Pooled it
  7. Magnesium sulphate versus diazepam for eclampsia.The Cochrane database of systematic reviews · 2010
    Pooled it
  8. Magnesium sulphate versus phenytoin for eclampsia.The Cochrane database of systematic reviews · 2010
    Pooled it
  9. Magnesium sulphate versus lytic cocktail for eclampsia.The Cochrane database of systematic reviews · 2010
    Pooled it
  10. Pooled it
  11. Pooled it
  12. Diuretics for preventing pre-eclampsia.The Cochrane database of systematic reviews · 2007
    Pooled it
  13. Trial
  14. Article
  15. Review
  16. Review
  17. Review
  18. Magnesium-permeableSpringerPlus · 2016
    Article
  19. Review
  20. TRPM channels and magnesium in early embryonic development.The International journal of developmental biology · 2015
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

M MakridesChild Nutrition Research Centre, Child Health Research Institute, Women's and Children's Hospital, 72 King William Road, North Adelaide, SA, Australia, 5006. makridesm@mail.wch.sa.gov.au
C A Crowther

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany women, especially those from disadvantaged backgrounds, have intakes of magnesium below recommended levels. Magnesium supplementation during pregnancy may be able to reduce fetal growth retardation and pre-eclampsia, and increase birth weight.

objectivesThe objective of this review was to assess the effects of magnesium supplementation during pregnancy on maternal, neonatal and paediatric outcomes. SEARCH STRATEGY: We searched the Cochrane Cochrane Controlled Trials Register. The date of the last search was June 2001. SELECTION CRITERIA: Randomised and quasi-randomised trials of dietary magnesium supplementation during pregnancy. DATA COLLECTION AND ANALYSIS: Suitability for inclusion and methodological quality were separately assessed by each reviewer. Data were independently extracted by the two reviewers. MAIN

resultsSeven trials involving 2689 women were included. Six of these trials randomly allocated women to either an oral magnesium supplement or a control group, whist the largest trial with 985 women had a cluster design where randomisation was according to study centre. The analysis was conducted with and without the cluster trial. In the analysis of all trials, oral magnesium treatment from before the 25th week of gestation was associated with a lower frequency of preterm birth, (relative risk (RR) 0.73, 95% confidence interval (CI) 0.57 to 0.94), a lower frequency of low birth weight (RR 0.67, 95% CI 0.46 to 0.96) and fewer small for gestational age infants (RR 0.70, 95% CI 0.53 to 0.93) compared with placebo. In addition, magnesium treated women had less hospitalisations during pregnancy (RR 0.66, 95% CI 0.49 to 0.89) and fewer cases of antepartum haemorrhage (RR 0.38, 95% CI 0.16 to 0.90) than placebo treated women. In the analysis excluding the cluster randomised trial, the effects of magnesium treatment on the frequencies of preterm birth, low birth weight and small for gestational age were not different from placebo. Of the seven trials included in the review, only one was judged to be of high quality. Poor quality trials are likely to have resulted in a bias favouring magnesium supplementation. REVIEWER'S

conclusionsThere is not enough high quality evidence to show that dietary magnesium supplementation during pregnancy is beneficial.

Indexed as

Dietary SupplementsPregnancyFemaleHumansMagnesiumPregnancy, High-RiskPregnancy OutcomeMagnesium

Identifiers

PMID11687087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.