ArticleAnnals of surgery2001
Efficacy of medical therapy and antireflux surgery to prevent Barrett's metaplasia in patients with gastroesophageal reflux disease.
Article in Annals of surgery, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Treatment for Barrett's oesophagus.The Cochrane database of systematic reviews · 2010Pooled it
- The effect of antireflux surgery on esophageal carcinogenesis in patients with barrett esophagus: a systematic review.Annals of surgery · 2007Pooled it
- Division of the short gastric vessels during laparoscopic Nissen fundoplication: clinical and functional outcome during long-term follow-up in a prospectively randomized trial.Surgical endoscopy · 2009Trial
- Efficacy of Nissen Sleeve Gastrectomy on Mid-term Barrett's Esophagus Regression.Obesity surgery · 2024Article
- Laparoscopic Adjustable Gastric Banding: an Underestimated Risk Factor for the Development of Esophageal Cancer?-a Nationwide Survey.Obesity surgery · 2019Article
- Impact of gastroesophageal reflux control through tailored proton pump inhibition therapy or fundoplication in patients with Barrett's esophagus.World journal of gastroenterology · 2017Article
- BOB CAT: A Large-Scale Review and Delphi Consensus for Management of Barrett's Esophagus With No Dysplasia, Indefinite for, or Low-Grade Dysplasia.The American journal of gastroenterology · 2015Review
- Importance of a multidisciplinary approach for the treatment of Barrett's esophagus.Updates in surgery · 2011Review
- Reflux, Barrett's, and adenocarcinoma of the esophagus: can we disrupt the pathway?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2010Article
- Vagal nerve dissection during pouch formation in laparoscopic Roux-Y-gastric bypass for technical simplification: does it matter?Obesity surgery · 2009Article
- Gastroesophageal reflux disease: medical or surgical treatment?Gastroenterology research and practice · 2009Article
- Is a pouch compulsory in Roux-en-Y gastric bypass after failed adjustable gastric banding?Obesity surgery · 2008Article
- The Nissen fundoplication: indication, technical aspects and postoperative outcome.Langenbeck's archives of surgery · 2005Review
- Austrian experiences with redo antireflux surgery.Surgical endoscopy · 2005Article
- SAGES Appropriateness Conference: a summary.Surgical endoscopy · 2003Article
- Review
- [Laparoscopic fundoplication. Indications and results].Der Internist · 2003Article
- Quality of life in GERD patients: medical treatment versus antireflux surgery.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether Barrett's metaplasia may develop despite effective medical therapy. SUMMARY BACKGROUND DATA: Gastroesophageal reflux disease has a multifactorial etiology. Therefore, medical treatment may not prevent complications of reflux disease.
methodsEighty-three patients with reflux disease and mild esophagitis were prospectively studied for the development of Barrett's metaplasia while receiving long-term therapy with proton pump inhibitors and cisapride. Only patients who had effective control of reflux symptoms and esophagitis were included. The surveillance time was 2 years. The outcome of these 83 patients was compared with that of 42 patients in whom antireflux surgery was performed with a median follow-up of 3.5 years.
resultsTwelve (14.5%) patients developed Barrett's while receiving medical therapy; this was not seen after surgery. Patients developing Barrett's had a weaker lower esophageal sphincter and peristalsis before treatment than patients with uncomplicated disease.
conclusionsAntireflux surgery is superior to medical therapy in the prevention of Barrett's metaplasia. Therefore, patients with reflux disease who have a weak lower esophageal sphincter and poor esophageal peristalsis should undergo antireflux surgery, even if they have only mild esophagitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.