ArticleRNA (New York, N.Y.)2001
Poly(A)-binding proteins regulate both mRNA deadenylation and decapping in yeast cytoplasmic extracts.
Article in RNA (New York, N.Y.), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
51 citing papers in PubMed, 97 citations in OpenAlex.
- Prognostic significance and biological implications of SM-like genes in mantle cell lymphoma.Blood research · 2024Article
- Genome-Wide and Comprehensive Analysis of the Multiple Stress-Related CAF1 (CCR4-Associated Factor 1) Family and Its Expression in Poplar.Plants (Basel, Switzerland) · 2021Article
- A CCR4-associated factor 1, OsCAF1B, confers tolerance of low-temperature stress to rice seedlings.Plant molecular biology · 2021Article
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- Plant growth and fertility requires functional interactions between specific PABP and eIF4G gene family members.PloS one · 2018Article
- Class II members of the poly(A) binding protein family exhibit distinct functions during Arabidopsis growth and development.Translation (Austin, Tex.) · 2017Article
- Article
- Cytoplasmic poly(A) binding protein-1 binds to genomically encoded sequences within mammalian mRNAs.RNA (New York, N.Y.) · 2016Article
- AUF-1 and YB-1 independently regulate β-globin mRNA in developing erythroid cells through interactions with poly(A)-binding protein.Mechanisms of development · 2015Article
- Elimination of cap structures generated by mRNA decay involves the new scavenger mRNA decapping enzyme Aph1/FHIT together with DcpS.Nucleic acids research · 2015Article
- Phylogenetic analysis reveals dynamic evolution of the poly(A)-binding protein gene family in plants.BMC evolutionary biology · 2014Article
- Aspergillus oryzae AoSO is a novel component of stress granules upon heat stress in filamentous fungi.PloS one · 2013Article
- A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expression.PLoS pathogens · 2011Article
- Loss of PTB or negative regulation of Notch mRNA reveals distinct zones of Notch and actin protein accumulation in Drosophila embryo.PloS one · 2011Article
- Tethering of poly(A)-binding protein interferes with non-translated mRNA decay from the 5' end in yeast.The Journal of biological chemistry · 2010Article
- Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies.The FEBS journal · 2010Article
- Notch and delta mRNAs in early-stage and mid-stage drosophila embryos exhibit complementary patterns of protein-producing potentials.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression.RNA (New York, N.Y.) · 2010Article
- Notch mRNA expression in Drosophila embryos is negatively regulated at the level of mRNA 3' processing.PloS one · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The pathway of mRNA degradation has been extensively studied in the yeast, Saccharomyces cerevisiae, and it is now clear that many mRNAs decay by a deadenylation-dependent mechanism. Although several of the factors required for mRNA decay have been identified, the regulation and precise roles of many of the proteins involved remains unclear. We have developed an in vitro system that recapitulates both the deadenylation and the decapping steps of mRNA decay. Furthermore, both deadenylation and decapping are inhibited by poly(A) binding proteins in our assay. Our system has allowed us to separate the decay process from translation and we have shown that the poly(A) tail is capable of inhibiting decapping in an eIF4E-independent manner. Our in vitro system should prove invaluable in dissecting the mechanisms of mRNA turnover.
Indexed as
Identifiers
11680846PMC1370185W2161448011What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.