ArticleDigestive diseases and sciences2001
Hydrocortisone treatment of early SIRS in acute experimental pancreatitis.
Article in Digestive diseases and sciences, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Efficacy of glucocorticoids in rodents of severe acute pancreatitis: a meta-analysis.International journal of clinical and experimental pathology · 2014Pooled it
- Comparable organs weights and histopathological changes after administration of dexamethasone during pregnancy in rats.Open veterinary journal · 2026Article
- Corticosteroid treatment for acute/acute-on-chronic experimental and naturally occurring pancreatitis in several species: a scoping review to inform possible use in dogs.Acta veterinaria Scandinavica · 2021Article
- Methods for prevention of acute post-endoscopic retrograde cholangiopancreatography pancreatitis.Przeglad gastroenterologiczny · 2020Review
- Pharmacologic therapy for acute pancreatitis.World journal of gastroenterology · 2014Review
- Immune-modulating therapy in acute pancreatitis: fact or fiction.World journal of gastroenterology · 2014Review
- Article
- Pharmacological approach to acute pancreatitis.World journal of gastroenterology · 2008Review
- Relative adrenal insufficiency in patients with severe acute pancreatitis.Intensive care medicine · 2007Article
- Effect of Tetrandrine on LPS-induced NF-kappaB activation in isolated pancreatic acinar cells of rat.World journal of gastroenterology · 2006Article
- Influence of hydrocortisone, prednisolone, and NO association on the evolution of acute pancreatitis.Digestive diseases and sciences · 2006Article
- Tumor necrosis factor alpha antibody prevents brain damage of rats with acute necrotizing pancreatitis.World journal of gastroenterology · 2004Article
- Dexamethasone and dextran 40 treatment of 32 patients with severe acute pancreatitis.World journal of gastroenterology · 2004Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work studied the effects of hydrocortisone treatment in experimental acute pancreatitis on cytokines, phospholipase A2, and breakdown products of arachidonic acid and survival. Edematous and necrotizing pancreatitis were induced in Wistar rats by cerulein hyperstimulation and retrograde intraductal infusion of sodium taurocholate, respectively. Hydrocortisone (10 mg/kg) was administered intravenously 10 minutes after induction of acute pancreatitis. Serum was assayed for phospholipase A2; interleukin (IL) 1beta, IL-6, IL-10, thromboxane B2; Prostaglandin E2; and leukotriene B4 at five different time points. A significant release of inflammatory mediators was seen only in the severe model. Hydrocortisone powerfully suppressed arachidonic acid breakdown products and only mildly attenuated the systemic increase of phospholipase A2 and pro- and antiinflammatory cytokines. The mortality rate after 72 hr in the severe model was 86%. Hydrocortisone treatment reduced mortality to 13% (P = 0.001; Fisher's exact test). Hydrocortisone seems to be effective in the treatment of the early systemic inflammatory response syndrome associated with severe acute pancreatitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.