ArticleJapanese journal of cancer research : Gann2001
Reduced expression of syndecan-1 affects metastatic potential and clinical outcome in patients with colorectal cancer.
Article in Japanese journal of cancer research : Gann, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Prognostic and clinical significance of syndecan-1 in colorectal cancer: a meta-analysis.BMC gastroenterology · 2015Pooled it
- Meta-analysis of histopathological features of primary colorectal cancers that predict lymph node metastases.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Pooled it
- Heparan Sulfate Glycosaminoglycans: (Un)Expected Allies in Cancer Clinical Management.Biomolecules · 2021Review
- Syndecan-1 Promotes Hepatocyte-Like Differentiation of Hepatoma Cells Targeting Ets-1 and AP-1.Biomolecules · 2020Article
- Multiplex Soluble Biomarker Analysis from Pleural Effusion.Biomolecules · 2020Article
- Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells.Frontiers in oncology · 2020Article
- Loss of SDC1 Expression Is Associated with Poor Prognosis of Colorectal Cancer Patients in Northern China.Disease markers · 2019Article
- Heparan Sulfate Proteoglycans in Human Colorectal Cancer.Analytical cellular pathology (Amsterdam) · 2018Review
- Tissue microarray analysis delineate potential prognostic role of Annexin A7 in prostate cancer progression.PloS one · 2018Article
- Prognostic impact of tumour-associated B cells and plasma cells in oesophageal and gastric adenocarcinoma.Journal of gastrointestinal oncology · 2016Article
- Mammary serine protease inhibitor and CD138 immunohistochemical expression in ovarian serous and clear cell carcinomas.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- High glucose-induced intestinal epithelial barrier damage is aggravated by syndecan-1 destruction and heparanase overexpression.Journal of cellular and molecular medicine · 2015Article
- Shed Syndecan-1 is involved in chemotherapy resistance via the EGFR pathway in colorectal cancer.British journal of cancer · 2014Article
- Diagnostic and prognostic value of soluble syndecan-1 in pleural malignancies.BioMed research international · 2014Article
- Expression of syndecan-4 and correlation with metastatic potential in testicular germ cell tumours.BioMed research international · 2013Article
- Breast and ovarian cancers: a survey and possible roles for the cell surface heparan sulfate proteoglycans.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Review
- Estrogen receptor β induces antiinflammatory and antitumorigenic networks in colon cancer cells.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Endogenous synthesis of n-3 polyunsaturated fatty acids in Fat-1 mice is associated with increased mammary gland and liver syndecan-1.PloS one · 2011Article
- Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget.Oncotarget · 2010Review
- The expression of syndecan-1 is related to the risk of endometrial hyperplasia progressing to endometrial carcinoma.Journal of gynecologic oncology · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Syndecan-1 is a transmembrane heparansulfate proteoglycan which regulates cell-to-cell or cell-to-extracellular matrix interactions and may influence malignant cell behavior. We investigated the alterations of syndecan-1 expressions in colorectal cancers and analyzed the relationship between histological and clinical characteristics. Syndecan-1 protein expression in colorectal cancer tissues was investigated with immunohistochemical staining of resected specimens. In situ hybridization was performed using syndecan-1 riboprobe to confirm the transcriptional signals. Syndecan-1 mRNA expression in cancer cell lines cultured with or without methylation inhibitor was also analyzed by quantitative PCR. Out of 105 specimens tested, less than 25% of tumor cells were stained with anti-syndecan-1 monoclonal antibody in 36 (34.3%). In situ hybridization showed a similar staining profile to that of immunohistochemistry. Syndecan-1 mRNA expression was increased by the methylation inhibitor 5-aza-2'-deoxycytidine, suggesting that the hypermethylation is involved in the suppression of syndecan-1 expression. Clinically, the incidence of metastasis to lymphnode or liver in patients with syndecan-1-negative tumors was significantly high. Among T1 colorectal cancers displaying a primary invasive phase, lymphnode metastasis, undifferentiated characters and 'budding' of cancer cells were more common in syndecan-1-negative tumors. The survival rate in patients with syndecan-1-negative tumors was decreased significantly in a stage-independent manner. These results suggest that the reduction of syndecan-1 expression in colorectal cancer cells, which is supposed to be regulated at the transcription level, is closely related to invasive character. The evaluation of syndecan-1 expression in colorectal cancer may allow prediction of patients' survival after surgery.
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